| 1 | 1 | Aug 28, 2021 | 2:00 PM | Sat | Fresno State | 45 | | Connecticut | 0 | |
| 2 | 1 | Aug 28, 2021 | 1:20 PM | Sat | Illinois | 30 | | Nebraska | 22 | |
| 3 | 1 | Aug 28, 2021 | 10:00 PM | Sat | San Jose State | 45 | | Southern Utah | 14 | |
| 4 | 1 | Aug 28, 2021 | 9:30 PM | Sat | Texas-El Paso | 30 | @ | New Mexico State | 3 | |
| 5 | 1 | Aug 28, 2021 | 3:30 PM | Sat | UCLA | 44 | | Hawaii | 10 | |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 6 | 2 | Sep 1, 2021 | 7:30 PM | Wed | Alabama-Birmingham | 31 | N | Jacksonville State | 0 | Cramton Bowl - Montgomery, Alabama |
| 7 | 2 | Sep 2, 2021 | 7:30 PM | Thu | Appalachian State | 33 | N | East Carolina | 19 | Bank of America Stadium - Charlotte, North Carolina |
| 8 | 2 | Sep 2, 2021 | 10:30 PM | Thu | (25) Arizona State | 41 | | Southern Utah | 14 | |
| 9 | 2 | Sep 2, 2021 | 7:00 PM | Thu | Ball State | 31 | | Western Illinois | 21 | |
| 10 | 2 | Sep 2, 2021 | 7:00 PM | Thu | Buffalo | 69 | | Wagner | 7 | |
| 11 | 2 | Sep 2, 2021 | 7:30 PM | Thu | California-Davis | 19 | @ | Tulsa | 17 | |
| 12 | 2 | Sep 2, 2021 | 7:00 PM | Thu | Central Florida | 36 | | Boise State | 31 | |
| 13 | 2 | Sep 2, 2021 | 7:00 PM | Thu | (22) Coastal Carolina | 52 | | Citadel | 14 | |
| 14 | 2 | Sep 2, 2021 | 10:00 PM | Thu | Eastern Washington | 35 | @ | Nevada-Las Vegas | 33 | |
| 15 | 2 | Sep 2, 2021 | 8:05 PM | Thu | Florida International | 48 | | Long Island | 10 | |
| 16 | 2 | Sep 2, 2021 | 8:00 PM | Thu | New Mexico | 27 | | Houston Baptist | 17 | |
| 17 | 2 | Sep 2, 2021 | 7:30 PM | Thu | North Carolina State | 45 | | South Florida | 0 | |
| 18 | 2 | Sep 2, 2021 | 8:00 PM | Thu | (4) Ohio State | 45 | @ | Minnesota | 31 | |
| 19 | 2 | Sep 2, 2021 | 8:00 PM | Thu | Tennessee | 38 | | Bowling Green | 6 | |
| 20 | 2 | Sep 2, 2021 | 7:30 PM | Thu | (24) Utah | 40 | | Weber State | 17 | |
| 21 | 2 | Sep 2, 2021 | 8:00 PM | Thu | Western Kentucky | 59 | | Tennessee-Martin | 21 | |
| 22 | 2 | Sep 3, 2021 | 7:00 PM | Fri | Charlotte | 31 | | Duke | 28 | |
| 23 | 2 | Sep 3, 2021 | 9:00 PM | Fri | Colorado | 35 | | Northern Colorado | 7 | |
| 24 | 2 | Sep 3, 2021 | 7:00 PM | Fri | Eastern Michigan | 35 | | St. Francis (PA) | 15 | |
| 25 | 2 | Sep 3, 2021 | 8:00 PM | Fri | Kansas | 17 | | South Dakota | 14 | |
| 26 | 2 | Sep 3, 2021 | 9:00 PM | Fri | Michigan State | 38 | @ | Northwestern | 21 | |
| 27 | 2 | Sep 3, 2021 | 9:00 PM | Fri | South Dakota State | 42 | @ | Colorado State | 23 | |
| 28 | 2 | Sep 3, 2021 | 6:00 PM | Fri | Virginia Tech | 17 | | (10) North Carolina | 10 | |
| 29 | 2 | Sep 3, 2021 | 7:00 PM | Fri | Wake Forest | 42 | | Old Dominion | 10 | |
| 30 | 2 | Sep 4, 2021 | 2:00 PM | Sat | Air Force | 35 | | Lafayette | 14 | |
| 31 | 2 | Sep 4, 2021 | 3:30 PM | Sat | (1) Alabama | 44 | N | (14) Miami (FL) | 13 | Mercedes-Benz Stadium - Atlanta, Georgia |
| 32 | 2 | Sep 4, 2021 | 2:00 PM | Sat | Arkansas | 38 | | Rice | 17 | |
| 33 | 2 | Sep 4, 2021 | 7:00 PM | Sat | Arkansas State | 40 | | Central Arkansas | 21 | |
| 34 | 2 | Sep 4, 2021 | 12:00 PM | Sat | Army | 43 | @ | Georgia State | 10 | |
| 35 | 2 | Sep 4, 2021 | 7:00 PM | Sat | Auburn | 60 | | Akron | 10 | |
| 36 | 2 | Sep 4, 2021 | 7:00 PM | Sat | Baylor | 29 | @ | Texas State | 20 | |
| 37 | 2 | Sep 4, 2021 | 12:00 PM | Sat | Boston College | 51 | | Colgate | 0 | |
| 38 | 2 | Sep 4, 2021 | 10:30 PM | Sat | Brigham Young | 24 | N | Arizona | 16 | Allegiant Stadium - Paradise, Nevada |
| 39 | 2 | Sep 4, 2021 | 3:30 PM | Sat | (8) Cincinnati | 49 | | Miami (OH) | 14 | |
| 40 | 2 | Sep 4, 2021 | 8:00 PM | Sat | East Tennessee State | 23 | @ | Vanderbilt | 3 | |
| 41 | 2 | Sep 4, 2021 | 7:30 PM | Sat | (13) Florida | 35 | | Florida Atlantic | 14 | |
| 42 | 2 | Sep 4, 2021 | 7:30 PM | Sat | (5) Georgia | 10 | N | (3) Clemson | 3 | Bank of America Stadium - Charlotte, North Carolina |
| 43 | 2 | Sep 4, 2021 | 6:00 PM | Sat | Georgia Southern | 30 | | Gardner-Webb | 25 | |
| 44 | 2 | Sep 4, 2021 | 11:59 PM | Sat | Hawaii | 49 | | Portland State | 35 | |
| 45 | 2 | Sep 4, 2021 | 12:00 PM | Sat | Holy Cross | 38 | @ | Connecticut | 28 | |
| 46 | 2 | Sep 4, 2021 | 3:30 PM | Sat | (18) Iowa | 34 | | (17) Indiana | 6 | |
| 47 | 2 | Sep 4, 2021 | 4:30 PM | Sat | (7) Iowa State | 16 | | Northern Iowa | 10 | |
| 48 | 2 | Sep 4, 2021 | 12:00 PM | Sat | Kansas State | 24 | N | Stanford | 7 | AT&T Stadium - Arlington, Texas |
| 49 | 2 | Sep 4, 2021 | 12:00 PM | Sat | Kentucky | 45 | | Louisiana-Monroe | 10 | |
| 50 | 2 | Sep 4, 2021 | 6:00 PM | Sat | Liberty | 48 | | Campbell | 7 | |
| 51 | 2 | Sep 4, 2021 | 3:30 PM | Sat | Marshall | 49 | @ | Navy | 7 | |
| 52 | 2 | Sep 4, 2021 | 3:30 PM | Sat | Maryland | 30 | | West Virginia | 24 | |
| 53 | 2 | Sep 4, 2021 | 7:00 PM | Sat | Memphis | 42 | | Nicholls State | 17 | |
| 54 | 2 | Sep 4, 2021 | 12:00 PM | Sat | Michigan | 47 | | Western Michigan | 14 | |
| 55 | 2 | Sep 4, 2021 | 7:00 PM | Sat | Middle Tennessee State | 50 | | Monmouth | 15 | |
| 56 | 2 | Sep 4, 2021 | 4:00 PM | Sat | Mississippi State | 35 | | Louisiana Tech | 34 | |
| 57 | 2 | Sep 4, 2021 | 4:00 PM | Sat | Missouri | 34 | | Central Michigan | 24 | |
| 58 | 2 | Sep 4, 2021 | 8:00 PM | Sat | Montana | 13 | @ | (20) Washington | 7 | |
| 59 | 2 | Sep 4, 2021 | 12:00 PM | Sat | Nebraska | 52 | | Fordham | 7 | |
| 60 | 2 | Sep 4, 2021 | 10:30 PM | Sat | Nevada | 22 | @ | California | 17 | |
| 61 | 2 | Sep 4, 2021 | 7:30 PM | Sat | North Texas | 44 | | Northwestern State | 14 | |
| 62 | 2 | Sep 4, 2021 | 7:30 PM | Sat | Northern Illinois | 22 | @ | Georgia Tech | 21 | |
| 63 | 2 | Sep 4, 2021 | 12:00 PM | Sat | (2) Oklahoma | 40 | | Tulane | 35 | |
| 64 | 2 | Sep 4, 2021 | 7:00 PM | Sat | Oklahoma State | 23 | | Missouri State | 16 | |
| 65 | 2 | Sep 4, 2021 | 2:00 PM | Sat | (11) Oregon | 31 | | Fresno State | 24 | |
| 66 | 2 | Sep 4, 2021 | 12:00 PM | Sat | (19) Penn State | 16 | @ | (12) Wisconsin | 10 | |
| 67 | 2 | Sep 4, 2021 | 4:00 PM | Sat | Pittsburgh | 51 | | Massachusetts | 7 | |
| 68 | 2 | Sep 4, 2021 | 7:00 PM | Sat | Purdue | 30 | | Oregon State | 21 | |
| 69 | 2 | Sep 4, 2021 | 12:00 PM | Sat | Rutgers | 61 | | Temple | 14 | |
| 70 | 2 | Sep 4, 2021 | 10:30 PM | Sat | San Diego State | 28 | | New Mexico State | 10 | |
| 71 | 2 | Sep 4, 2021 | 8:00 PM | Sat | South Alabama | 31 | | Southern Mississippi | 7 | |
| 72 | 2 | Sep 4, 2021 | 7:00 PM | Sat | South Carolina | 46 | | Eastern Illinois | 0 | |
| 73 | 2 | Sep 4, 2021 | 5:00 PM | Sat | (15) Southern California | 30 | | San Jose State | 7 | |
| 74 | 2 | Sep 4, 2021 | 7:00 PM | Sat | Southern Methodist | 56 | | Abilene Christian | 9 | |
| 75 | 2 | Sep 4, 2021 | 7:00 PM | Sat | Syracuse | 29 | @ | Ohio | 9 | |
| 76 | 2 | Sep 4, 2021 | 4:30 PM | Sat | (21) Texas | 38 | | (23) Louisiana | 18 | |
| 77 | 2 | Sep 4, 2021 | 8:00 PM | Sat | (6) Texas A&M | 41 | | Kent State | 10 | |
| 78 | 2 | Sep 4, 2021 | 8:00 PM | Sat | Texas Christian | 45 | | Duquesne | 3 | |
| 79 | 2 | Sep 4, 2021 | 7:00 PM | Sat | Texas Tech | 38 | N | Houston | 21 | NRG Stadium - Houston, Texas |
| 80 | 2 | Sep 4, 2021 | 9:00 PM | Sat | Texas-El Paso | 38 | | Bethune-Cookman | 28 | |
| 81 | 2 | Sep 4, 2021 | 7:30 PM | Sat | Texas-San Antonio | 37 | @ | Illinois | 30 | |
| 82 | 2 | Sep 4, 2021 | 7:00 PM | Sat | Toledo | 49 | | Norfolk State | 10 | |
| 83 | 2 | Sep 4, 2021 | 7:00 PM | Sat | Troy | 55 | | Southern | 3 | |
| 84 | 2 | Sep 4, 2021 | 8:30 PM | Sat | UCLA | 38 | | (16) Louisiana State | 27 | |
| 85 | 2 | Sep 4, 2021 | 11:00 PM | Sat | Utah State | 26 | @ | Washington State | 23 | |
| 86 | 2 | Sep 4, 2021 | 7:30 PM | Sat | Virginia | 43 | | William & Mary | 0 | |
| 87 | 2 | Sep 4, 2021 | 4:00 PM | Sat | Wyoming | 19 | | Montana State | 16 | |
| 88 | 2 | Sep 5, 2021 | 7:44 PM | Sun | (9) Notre Dame | 41 | @ | Florida State | 38 | |
| 89 | 2 | Sep 6, 2021 | 8:00 PM | Mon | Mississippi | 43 | N | Louisville | 24 | Mercedes-Benz Stadium - Atlanta, Georgia |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 90 | 3 | Sep 10, 2021 | 9:30 PM | Fri | Boise State | 54 | | Texas-El Paso | 13 | |
| 91 | 3 | Sep 10, 2021 | 7:30 PM | Fri | (17) Coastal Carolina | 49 | | Kansas | 22 | |
| 92 | 3 | Sep 10, 2021 | 8:00 PM | Fri | Duke | 45 | | North Carolina A&T | 17 | |
| 93 | 3 | Sep 10, 2021 | 9:00 PM | Fri | Utah State | 48 | | North Dakota | 24 | |
| 94 | 3 | Sep 11, 2021 | 3:30 PM | Sat | Air Force | 23 | @ | Navy | 3 | |
| 95 | 3 | Sep 11, 2021 | 4:00 PM | Sat | (1) Alabama | 48 | | Mercer | 14 | |
| 96 | 3 | Sep 11, 2021 | 10:30 PM | Sat | (23) Arizona State | 37 | | Nevada-Las Vegas | 10 | |
| 97 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Arkansas | 40 | | (15) Texas | 21 | |
| 98 | 3 | Sep 11, 2021 | 11:30 AM | Sat | Army | 38 | | Western Kentucky | 35 | |
| 99 | 3 | Sep 11, 2021 | 12:00 PM | Sat | (25) Auburn | 62 | | Alabama State | 0 | |
| 100 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Baylor | 66 | | Texas Southern | 7 | |
| 101 | 3 | Sep 11, 2021 | 3:30 PM | Sat | Boston College | 45 | @ | Massachusetts | 28 | |
| 102 | 3 | Sep 11, 2021 | 10:15 PM | Sat | Brigham Young | 26 | | (21) Utah | 17 | |
| 103 | 3 | Sep 11, 2021 | 6:30 PM | Sat | Central Florida | 63 | | Bethune-Cookman | 14 | |
| 104 | 3 | Sep 11, 2021 | 3:00 PM | Sat | Central Michigan | 45 | | Robert Morris | 0 | |
| 105 | 3 | Sep 11, 2021 | 6:00 PM | Sat | Charlotte | 38 | | Gardner-Webb | 10 | |
| 106 | 3 | Sep 11, 2021 | 3:30 PM | Sat | (7) Cincinnati | 42 | | Murray State | 7 | |
| 107 | 3 | Sep 11, 2021 | 5:00 PM | Sat | (6) Clemson | 49 | | South Carolina State | 3 | |
| 108 | 3 | Sep 11, 2021 | 2:00 PM | Sat | Duquesne | 28 | @ | Ohio | 26 | |
| 109 | 3 | Sep 11, 2021 | 1:00 PM | Sat | (13) Florida | 42 | @ | South Florida | 20 | |
| 110 | 3 | Sep 11, 2021 | 3:30 PM | Sat | Florida Atlantic | 38 | | Georgia Southern | 6 | |
| 111 | 3 | Sep 11, 2021 | 10:00 PM | Sat | Fresno State | 63 | | Cal Poly | 10 | |
| 112 | 3 | Sep 11, 2021 | 3:30 PM | Sat | (2) Georgia | 56 | | Alabama-Birmingham | 7 | |
| 113 | 3 | Sep 11, 2021 | 12:00 PM | Sat | Georgia Tech | 45 | | Kennesaw State | 17 | |
| 114 | 3 | Sep 11, 2021 | 6:30 PM | Sat | Houston | 44 | @ | Rice | 7 | |
| 115 | 3 | Sep 11, 2021 | 7:30 PM | Sat | Indiana | 56 | | Idaho | 14 | |
| 116 | 3 | Sep 11, 2021 | 4:30 PM | Sat | (10) Iowa | 27 | @ | (9) Iowa State | 17 | |
| 117 | 3 | Sep 11, 2021 | 8:00 PM | Sat | Jacksonville State | 20 | @ | Florida State | 17 | |
| 118 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Kansas State | 31 | | Southern Illinois | 23 | |
| 119 | 3 | Sep 11, 2021 | 11:30 AM | Sat | Kent State | 60 | | Virginia Military Institute | 10 | |
| 120 | 3 | Sep 11, 2021 | 7:30 PM | Sat | Kentucky | 35 | | Missouri | 28 | |
| 121 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Liberty | 21 | @ | Troy | 13 | |
| 122 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Louisiana | 27 | | Nicholls State | 24 | |
| 123 | 3 | Sep 11, 2021 | 8:00 PM | Sat | Louisiana State | 34 | | McNeese State | 7 | |
| 124 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Louisiana Tech | 45 | | Southeastern Louisiana | 42 | |
| 125 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Louisville | 30 | | Eastern Kentucky | 3 | |
| 126 | 3 | Sep 11, 2021 | 6:30 PM | Sat | Marshall | 44 | | North Carolina Central | 10 | |
| 127 | 3 | Sep 11, 2021 | 7:30 PM | Sat | Maryland | 62 | | Howard | 0 | |
| 128 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Memphis | 55 | @ | Arkansas State | 50 | |
| 129 | 3 | Sep 11, 2021 | 7:00 PM | Sat | (22) Miami (FL) | 25 | | Appalachian State | 23 | |
| 130 | 3 | Sep 11, 2021 | 8:00 PM | Sat | Michigan | 31 | | Washington | 10 | |
| 131 | 3 | Sep 11, 2021 | 12:00 PM | Sat | Michigan State | 42 | | Youngstown State | 14 | |
| 132 | 3 | Sep 11, 2021 | 12:00 PM | Sat | Minnesota | 31 | | Miami (OH) | 26 | |
| 133 | 3 | Sep 11, 2021 | 7:30 PM | Sat | (20) Mississippi | 54 | | Austin Peay | 17 | |
| 134 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Mississippi State | 24 | | North Carolina State | 10 | |
| 135 | 3 | Sep 11, 2021 | 3:30 PM | Sat | Nebraska | 28 | | Buffalo | 3 | |
| 136 | 3 | Sep 11, 2021 | 10:30 PM | Sat | Nevada | 49 | | Idaho State | 10 | |
| 137 | 3 | Sep 11, 2021 | 7:00 PM | Sat | New Mexico | 34 | | New Mexico State | 25 | |
| 138 | 3 | Sep 11, 2021 | 7:30 PM | Sat | (24) North Carolina | 59 | | Georgia State | 17 | |
| 139 | 3 | Sep 11, 2021 | 12:00 PM | Sat | Northwestern | 24 | | Indiana State | 6 | |
| 140 | 3 | Sep 11, 2021 | 2:30 PM | Sat | (8) Notre Dame | 32 | | Toledo | 29 | |
| 141 | 3 | Sep 11, 2021 | 7:00 PM | Sat | (4) Oklahoma | 76 | | Western Carolina | 0 | |
| 142 | 3 | Sep 11, 2021 | 12:00 PM | Sat | Oklahoma State | 28 | | Tulsa | 23 | |
| 143 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Old Dominion | 47 | | Hampton | 7 | |
| 144 | 3 | Sep 11, 2021 | 12:00 PM | Sat | (12) Oregon | 35 | @ | (3) Ohio State | 28 | |
| 145 | 3 | Sep 11, 2021 | 11:00 PM | Sat | Oregon State | 45 | | Hawaii | 27 | |
| 146 | 3 | Sep 11, 2021 | 3:30 PM | Sat | (11) Penn State | 44 | | Ball State | 13 | |
| 147 | 3 | Sep 11, 2021 | 12:00 PM | Sat | Pittsburgh | 41 | @ | Tennessee | 34 | |
| 148 | 3 | Sep 11, 2021 | 3:00 PM | Sat | Purdue | 49 | @ | Connecticut | 0 | |
| 149 | 3 | Sep 11, 2021 | 2:00 PM | Sat | Rutgers | 17 | @ | Syracuse | 7 | |
| 150 | 3 | Sep 11, 2021 | 10:00 PM | Sat | San Diego State | 38 | @ | Arizona | 14 | |
| 151 | 3 | Sep 11, 2021 | 4:00 PM | Sat | South Alabama | 22 | @ | Bowling Green | 19 | |
| 152 | 3 | Sep 11, 2021 | 12:00 PM | Sat | South Carolina | 20 | @ | East Carolina | 17 | |
| 153 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Southern Methodist | 35 | | North Texas | 12 | |
| 154 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Southern Mississippi | 37 | | Grambling State | 0 | |
| 155 | 3 | Sep 11, 2021 | 10:30 PM | Sat | Stanford | 42 | @ | (14) Southern California | 28 | |
| 156 | 3 | Sep 11, 2021 | 3:30 PM | Sat | Temple | 45 | @ | Akron | 24 | |
| 157 | 3 | Sep 11, 2021 | 3:30 PM | Sat | (5) Texas A&M | 10 | N | Colorado | 7 | Empower Field at Mile High - Denver, Colorado |
| 158 | 3 | Sep 11, 2021 | 3:30 PM | Sat | Texas Christian | 34 | | California | 32 | |
| 159 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Texas State | 23 | @ | Florida International | 17 | |
| 160 | 3 | Sep 11, 2021 | 7:00 PM | Sat | Texas Tech | 28 | | Stephen F. Austin | 22 | |
| 161 | 3 | Sep 11, 2021 | 6:00 PM | Sat | Texas-San Antonio | 54 | | Lamar | 0 | |
| 162 | 3 | Sep 11, 2021 | 1:00 PM | Sat | Tulane | 69 | | Morgan State | 20 | |
| 163 | 3 | Sep 11, 2021 | 10:00 PM | Sat | Vanderbilt | 24 | @ | Colorado State | 21 | |
| 164 | 3 | Sep 11, 2021 | 11:00 AM | Sat | Virginia | 42 | | Illinois | 14 | |
| 165 | 3 | Sep 11, 2021 | 2:00 PM | Sat | (19) Virginia Tech | 35 | | Middle Tennessee State | 14 | |
| 166 | 3 | Sep 11, 2021 | 12:00 PM | Sat | Wake Forest | 41 | | Norfolk State | 16 | |
| 167 | 3 | Sep 11, 2021 | 6:00 PM | Sat | Washington State | 44 | | Portland State | 24 | |
| 168 | 3 | Sep 11, 2021 | 5:00 PM | Sat | West Virginia | 66 | | Long Island | 0 | |
| 169 | 3 | Sep 11, 2021 | 5:00 PM | Sat | Western Michigan | 28 | | Illinois State | 0 | |
| 170 | 3 | Sep 11, 2021 | 7:00 PM | Sat | (18) Wisconsin | 34 | | Eastern Michigan | 7 | |
| 171 | 3 | Sep 11, 2021 | 1:30 PM | Sat | Wyoming | 50 | @ | Northern Illinois | 43 | |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 172 | 4 | Sep 16, 2021 | 8:00 PM | Thu | Louisiana | 49 | | Ohio | 14 | |
| 173 | 4 | Sep 17, 2021 | 7:30 PM | Fri | Louisville | 42 | | Central Florida | 35 | |
| 174 | 4 | Sep 17, 2021 | 9:00 PM | Fri | Maryland | 20 | @ | Illinois | 17 | |
| 175 | 4 | Sep 18, 2021 | 3:30 PM | Sat | Akron | 35 | | Bryant | 14 | |
| 176 | 4 | Sep 18, 2021 | 3:30 PM | Sat | (1) Alabama | 31 | @ | (11) Florida | 29 | |
| 177 | 4 | Sep 18, 2021 | 7:30 PM | Sat | Alabama-Birmingham | 40 | @ | North Texas | 6 | |
| 178 | 4 | Sep 18, 2021 | 3:30 PM | Sat | Appalachian State | 44 | | Elon | 10 | |
| 179 | 4 | Sep 18, 2021 | 4:00 PM | Sat | (20) Arkansas | 45 | | Georgia Southern | 10 | |
| 180 | 4 | Sep 18, 2021 | 12:00 PM | Sat | Army | 52 | | Connecticut | 21 | |
| 181 | 4 | Sep 18, 2021 | 3:30 PM | Sat | Baylor | 45 | @ | Kansas | 7 | |
| 182 | 4 | Sep 18, 2021 | 12:00 PM | Sat | Boston College | 28 | @ | Temple | 3 | |
| 183 | 4 | Sep 18, 2021 | 5:00 PM | Sat | Bowling Green | 27 | | Murray State | 10 | |
| 184 | 4 | Sep 18, 2021 | 10:15 PM | Sat | (23) Brigham Young | 27 | | (19) Arizona State | 17 | |
| 185 | 4 | Sep 18, 2021 | 4:00 PM | Sat | California | 42 | | Sacramento State | 30 | |
| 186 | 4 | Sep 18, 2021 | 12:00 PM | Sat | (8) Cincinnati | 38 | @ | Indiana | 24 | |
| 187 | 4 | Sep 18, 2021 | 3:30 PM | Sat | (6) Clemson | 14 | | Georgia Tech | 8 | |
| 188 | 4 | Sep 18, 2021 | 12:00 PM | Sat | (16) Coastal Carolina | 28 | @ | Buffalo | 25 | |
| 189 | 4 | Sep 18, 2021 | 4:00 PM | Sat | Colorado State | 22 | @ | Toledo | 6 | |
| 190 | 4 | Sep 18, 2021 | 4:00 PM | Sat | Duke | 30 | | Northwestern | 23 | |
| 191 | 4 | Sep 18, 2021 | 6:00 PM | Sat | East Carolina | 42 | @ | Marshall | 38 | |
| 192 | 4 | Sep 18, 2021 | 3:30 PM | Sat | Eastern Michigan | 42 | @ | Massachusetts | 28 | |
| 193 | 4 | Sep 18, 2021 | 6:00 PM | Sat | Florida Atlantic | 45 | | Fordham | 14 | |
| 194 | 4 | Sep 18, 2021 | 10:45 PM | Sat | Fresno State | 40 | @ | (13) UCLA | 37 | |
| 195 | 4 | Sep 18, 2021 | 7:00 PM | Sat | (2) Georgia | 40 | | South Carolina | 13 | |
| 196 | 4 | Sep 18, 2021 | 7:00 PM | Sat | Georgia State | 20 | | Charlotte | 9 | |
| 197 | 4 | Sep 18, 2021 | 7:00 PM | Sat | Houston | 45 | | Grambling State | 0 | |
| 198 | 4 | Sep 18, 2021 | 7:00 PM | Sat | Incarnate Word | 42 | @ | Texas State | 34 | |
| 199 | 4 | Sep 18, 2021 | 3:30 PM | Sat | (5) Iowa | 30 | | Kent State | 7 | |
| 200 | 4 | Sep 18, 2021 | 10:30 PM | Sat | (14) Iowa State | 48 | @ | Nevada-Las Vegas | 3 | |
| 201 | 4 | Sep 18, 2021 | 2:00 PM | Sat | Kansas State | 38 | | Nevada | 17 | |
| 202 | 4 | Sep 18, 2021 | 12:00 PM | Sat | Kentucky | 28 | | Chattanooga | 23 | |
| 203 | 4 | Sep 18, 2021 | 6:00 PM | Sat | Liberty | 45 | | Old Dominion | 17 | |
| 204 | 4 | Sep 18, 2021 | 7:30 PM | Sat | Louisiana State | 49 | | Central Michigan | 21 | |
| 205 | 4 | Sep 18, 2021 | 8:00 PM | Sat | Louisiana-Monroe | 12 | | Jackson State | 7 | |
| 206 | 4 | Sep 18, 2021 | 4:00 PM | Sat | Memphis | 31 | | Mississippi State | 29 | |
| 207 | 4 | Sep 18, 2021 | 3:30 PM | Sat | Miami (OH) | 42 | | Long Island | 7 | |
| 208 | 4 | Sep 18, 2021 | 12:00 PM | Sat | (25) Michigan | 63 | | Northern Illinois | 10 | |
| 209 | 4 | Sep 18, 2021 | 12:00 PM | Sat | Michigan State | 38 | @ | (24) Miami (FL) | 17 | |
| 210 | 4 | Sep 18, 2021 | 1:00 PM | Sat | Minnesota | 30 | @ | Colorado | 0 | |
| 211 | 4 | Sep 18, 2021 | 8:00 PM | Sat | (17) Mississippi | 61 | | Tulane | 21 | |
| 212 | 4 | Sep 18, 2021 | 12:00 PM | Sat | Missouri | 59 | | Southeast Missouri State | 28 | |
| 213 | 4 | Sep 18, 2021 | 8:00 PM | Sat | New Mexico State | 43 | | South Carolina State | 35 | |
| 214 | 4 | Sep 18, 2021 | 7:30 PM | Sat | (21) North Carolina | 59 | | Virginia | 39 | |
| 215 | 4 | Sep 18, 2021 | 7:30 PM | Sat | North Carolina State | 45 | | Furman | 7 | |
| 216 | 4 | Sep 18, 2021 | 10:00 PM | Sat | Northern Arizona | 21 | @ | Arizona | 19 | |
| 217 | 4 | Sep 18, 2021 | 2:30 PM | Sat | (12) Notre Dame | 27 | | Purdue | 13 | |
| 218 | 4 | Sep 18, 2021 | 3:30 PM | Sat | (9) Ohio State | 41 | | Tulsa | 20 | |
| 219 | 4 | Sep 18, 2021 | 12:00 PM | Sat | (3) Oklahoma | 23 | | Nebraska | 16 | |
| 220 | 4 | Sep 18, 2021 | 9:00 PM | Sat | Oklahoma State | 21 | @ | Boise State | 20 | |
| 221 | 4 | Sep 18, 2021 | 7:30 PM | Sat | (4) Oregon | 48 | | Stony Brook | 7 | |
| 222 | 4 | Sep 18, 2021 | 3:30 PM | Sat | Oregon State | 42 | | Idaho | 0 | |
| 223 | 4 | Sep 18, 2021 | 7:30 PM | Sat | (10) Penn State | 28 | | (22) Auburn | 20 | |
| 224 | 4 | Sep 18, 2021 | 3:30 PM | Sat | Rutgers | 45 | | Delaware | 13 | |
| 225 | 4 | Sep 18, 2021 | 7:00 PM | Sat | San Diego State | 33 | | Utah | 31 | |
| 226 | 4 | Sep 18, 2021 | 8:00 PM | Sat | South Alabama | 28 | | Alcorn State | 21 | |
| 227 | 4 | Sep 18, 2021 | 7:00 PM | Sat | South Florida | 38 | | Florida A&M | 17 | |
| 228 | 4 | Sep 18, 2021 | 3:30 PM | Sat | Southern California | 45 | @ | Washington State | 14 | |
| 229 | 4 | Sep 18, 2021 | 3:30 PM | Sat | Southern Methodist | 39 | @ | Louisiana Tech | 37 | |
| 230 | 4 | Sep 18, 2021 | 8:00 PM | Sat | Stanford | 41 | @ | Vanderbilt | 23 | |
| 231 | 4 | Sep 18, 2021 | 12:00 PM | Sat | Syracuse | 62 | | Albany | 24 | |
| 232 | 4 | Sep 18, 2021 | 12:00 PM | Sat | Tennessee | 56 | | Tennessee Tech | 0 | |
| 233 | 4 | Sep 18, 2021 | 8:00 PM | Sat | Texas | 58 | | Rice | 0 | |
| 234 | 4 | Sep 18, 2021 | 12:00 PM | Sat | (7) Texas A&M | 34 | | New Mexico | 0 | |
| 235 | 4 | Sep 18, 2021 | 7:00 PM | Sat | Texas Tech | 54 | | Florida International | 21 | |
| 236 | 4 | Sep 18, 2021 | 6:00 PM | Sat | Texas-San Antonio | 27 | | Middle Tennessee State | 13 | |
| 237 | 4 | Sep 18, 2021 | 7:00 PM | Sat | Troy | 21 | @ | Southern Mississippi | 9 | |
| 238 | 4 | Sep 18, 2021 | 7:30 PM | Sat | Utah State | 49 | @ | Air Force | 45 | |
| 239 | 4 | Sep 18, 2021 | 3:30 PM | Sat | Wake Forest | 35 | | Florida State | 14 | |
| 240 | 4 | Sep 18, 2021 | 4:15 PM | Sat | Washington | 52 | | Arkansas State | 3 | |
| 241 | 4 | Sep 18, 2021 | 12:00 PM | Sat | West Virginia | 27 | | (15) Virginia Tech | 21 | |
| 242 | 4 | Sep 18, 2021 | 12:00 PM | Sat | Western Michigan | 44 | @ | Pittsburgh | 41 | |
| 243 | 4 | Sep 18, 2021 | 4:00 PM | Sat | Wyoming | 45 | | Ball State | 12 | |
| 244 | 4 | Sep 19, 2021 | 12:30 AM | Sun | San Jose State | 17 | @ | Hawaii | 13 | |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 245 | 5 | Sep 23, 2021 | 7:35 PM | Thu | Appalachian State | 31 | | Marshall | 30 | |
| 246 | 5 | Sep 24, 2021 | 6:30 PM | Fri | Charlotte | 42 | | Middle Tennessee State | 39 | |
| 247 | 5 | Sep 24, 2021 | 10:00 PM | Fri | (22) Fresno State | 38 | | Nevada-Las Vegas | 30 | |
| 248 | 5 | Sep 24, 2021 | 8:00 PM | Fri | Syracuse | 24 | | Liberty | 21 | |
| 249 | 5 | Sep 24, 2021 | 7:00 PM | Fri | Wake Forest | 37 | @ | Virginia | 17 | |
| 250 | 5 | Sep 25, 2021 | 8:00 PM | Sat | Air Force | 31 | | Florida Atlantic | 7 | |
| 251 | 5 | Sep 25, 2021 | 7:30 PM | Sat | (1) Alabama | 63 | | Southern Mississippi | 14 | |
| 252 | 5 | Sep 25, 2021 | 8:00 PM | Sat | Alabama-Birmingham | 28 | @ | Tulane | 21 | |
| 253 | 5 | Sep 25, 2021 | 10:30 PM | Sat | Arizona State | 35 | | Colorado | 13 | |
| 254 | 5 | Sep 25, 2021 | 3:30 PM | Sat | (16) Arkansas | 20 | N | (7) Texas A&M | 10 | AT&T Stadium - Arlington, Texas |
| 255 | 5 | Sep 25, 2021 | 12:00 PM | Sat | Army | 23 | | Miami (OH) | 10 | |
| 256 | 5 | Sep 25, 2021 | 4:00 PM | Sat | (23) Auburn | 34 | | Georgia State | 24 | |
| 257 | 5 | Sep 25, 2021 | 3:30 PM | Sat | Baylor | 31 | | (14) Iowa State | 29 | |
| 258 | 5 | Sep 25, 2021 | 12:00 PM | Sat | Boise State | 27 | @ | Utah State | 3 | |
| 259 | 5 | Sep 25, 2021 | 12:00 PM | Sat | Boston College | 41 | | Missouri | 34 | |
| 260 | 5 | Sep 25, 2021 | 12:00 PM | Sat | Bowling Green | 14 | @ | Minnesota | 10 | |
| 261 | 5 | Sep 25, 2021 | 10:15 PM | Sat | (15) Brigham Young | 35 | | South Florida | 27 | |
| 262 | 5 | Sep 25, 2021 | 6:00 PM | Sat | Buffalo | 35 | @ | Old Dominion | 34 | |
| 263 | 5 | Sep 25, 2021 | 12:00 PM | Sat | Central Michigan | 31 | | Florida International | 27 | |
| 264 | 5 | Sep 25, 2021 | 1:00 PM | Sat | (17) Coastal Carolina | 53 | | Massachusetts | 3 | |
| 265 | 5 | Sep 25, 2021 | 4:00 PM | Sat | Duke | 52 | | Kansas | 33 | |
| 266 | 5 | Sep 25, 2021 | 6:00 PM | Sat | East Carolina | 31 | | Charleston Southern | 28 | |
| 267 | 5 | Sep 25, 2021 | 2:00 PM | Sat | Eastern Michigan | 59 | | Texas State | 21 | |
| 268 | 5 | Sep 25, 2021 | 7:00 PM | Sat | (11) Florida | 38 | | Tennessee | 14 | |
| 269 | 5 | Sep 25, 2021 | 12:00 PM | Sat | (2) Georgia | 62 | @ | Vanderbilt | 0 | |
| 270 | 5 | Sep 25, 2021 | 7:30 PM | Sat | Georgia Tech | 45 | N | (21) North Carolina | 22 | Mercedes-Benz Stadium - Atlanta, Georgia |
| 271 | 5 | Sep 25, 2021 | 8:00 PM | Sat | Hawaii | 41 | @ | New Mexico State | 21 | |
| 272 | 5 | Sep 25, 2021 | 7:00 PM | Sat | Houston | 28 | | Navy | 20 | |
| 273 | 5 | Sep 25, 2021 | 8:00 PM | Sat | Indiana | 33 | @ | Western Kentucky | 31 | |
| 274 | 5 | Sep 25, 2021 | 3:30 PM | Sat | (5) Iowa | 24 | | Colorado State | 14 | |
| 275 | 5 | Sep 25, 2021 | 7:00 PM | Sat | Kentucky | 16 | @ | South Carolina | 10 | |
| 276 | 5 | Sep 25, 2021 | 6:00 PM | Sat | Louisiana | 28 | @ | Georgia Southern | 20 | |
| 277 | 5 | Sep 25, 2021 | 12:00 PM | Sat | Louisiana State | 28 | @ | Mississippi State | 25 | |
| 278 | 5 | Sep 25, 2021 | 7:00 PM | Sat | Louisiana Tech | 24 | | North Texas | 17 | |
| 279 | 5 | Sep 25, 2021 | 8:00 PM | Sat | Louisiana-Monroe | 29 | | Troy | 16 | |
| 280 | 5 | Sep 25, 2021 | 3:30 PM | Sat | Louisville | 31 | @ | Florida State | 23 | |
| 281 | 5 | Sep 25, 2021 | 3:30 PM | Sat | Maryland | 37 | | Kent State | 16 | |
| 282 | 5 | Sep 25, 2021 | 12:30 PM | Sat | Miami (FL) | 69 | | Central Connecticut State | 0 | |
| 283 | 5 | Sep 25, 2021 | 3:30 PM | Sat | (19) Michigan | 20 | | Rutgers | 13 | |
| 284 | 5 | Sep 25, 2021 | 7:00 PM | Sat | (20) Michigan State | 23 | | Nebraska | 20 | |
| 285 | 5 | Sep 25, 2021 | 3:30 PM | Sat | North Carolina State | 27 | | (9) Clemson | 21 | |
| 286 | 5 | Sep 25, 2021 | 2:30 PM | Sat | Northern Illinois | 41 | | Maine | 14 | |
| 287 | 5 | Sep 25, 2021 | 12:00 PM | Sat | Northwestern | 35 | | Ohio | 6 | |
| 288 | 5 | Sep 25, 2021 | 12:00 PM | Sat | (12) Notre Dame | 41 | N | (18) Wisconsin | 13 | Soldier Field (Chicago, Illinois) |
| 289 | 5 | Sep 25, 2021 | 7:30 PM | Sat | (10) Ohio State | 59 | | Akron | 7 | |
| 290 | 5 | Sep 25, 2021 | 7:30 PM | Sat | (4) Oklahoma | 16 | | West Virginia | 13 | |
| 291 | 5 | Sep 25, 2021 | 7:00 PM | Sat | Oklahoma State | 31 | | (25) Kansas State | 20 | |
| 292 | 5 | Sep 25, 2021 | 10:30 PM | Sat | (3) Oregon | 41 | | Arizona | 19 | |
| 293 | 5 | Sep 25, 2021 | 10:30 PM | Sat | Oregon State | 45 | @ | Southern California | 27 | |
| 294 | 5 | Sep 25, 2021 | 12:00 PM | Sat | (6) Penn State | 38 | | Villanova | 17 | |
| 295 | 5 | Sep 25, 2021 | 12:00 PM | Sat | Pittsburgh | 77 | | New Hampshire | 7 | |
| 296 | 5 | Sep 25, 2021 | 3:30 PM | Sat | Purdue | 13 | | Illinois | 9 | |
| 297 | 5 | Sep 25, 2021 | 6:30 PM | Sat | Rice | 48 | | Texas Southern | 34 | |
| 298 | 5 | Sep 25, 2021 | 3:30 PM | Sat | San Diego State | 48 | | Towson | 21 | |
| 299 | 5 | Sep 25, 2021 | 12:00 PM | Sat | Southern Methodist | 42 | @ | Texas Christian | 34 | |
| 300 | 5 | Sep 25, 2021 | 12:00 PM | Sat | Temple | 41 | | Wagner | 7 | |
| 301 | 5 | Sep 25, 2021 | 12:00 PM | Sat | Texas | 70 | | Texas Tech | 35 | |
| 302 | 5 | Sep 25, 2021 | 9:00 PM | Sat | Texas-El Paso | 20 | | New Mexico | 13 | |
| 303 | 5 | Sep 25, 2021 | 3:30 PM | Sat | Texas-San Antonio | 31 | @ | Memphis | 28 | |
| 304 | 5 | Sep 25, 2021 | 2:00 PM | Sat | Toledo | 22 | @ | Ball State | 12 | |
| 305 | 5 | Sep 25, 2021 | 5:00 PM | Sat | Tulsa | 41 | | Arkansas State | 34 | |
| 306 | 5 | Sep 25, 2021 | 6:00 PM | Sat | (24) UCLA | 35 | @ | Stanford | 24 | |
| 307 | 5 | Sep 25, 2021 | 2:30 PM | Sat | Utah | 24 | | Washington State | 13 | |
| 308 | 5 | Sep 25, 2021 | 12:00 PM | Sat | Virginia Tech | 21 | | Richmond | 10 | |
| 309 | 5 | Sep 25, 2021 | 9:30 PM | Sat | Washington | 31 | | California | 24 | |
| 310 | 5 | Sep 25, 2021 | 2:00 PM | Sat | Western Michigan | 23 | | San Jose State | 3 | |
| 311 | 5 | Sep 25, 2021 | 3:30 PM | Sat | Wyoming | 24 | @ | Connecticut | 22 | |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 312 | 6 | Sep 30, 2021 | 7:30 PM | Thu | Virginia | 30 | @ | Miami (FL) | 28 | |
| 313 | 6 | Oct 1, 2021 | 9:00 PM | Fri | (13) Brigham Young | 34 | @ | Utah State | 20 | |
| 314 | 6 | Oct 1, 2021 | 6:35 PM | Fri | Houston | 45 | @ | Tulsa | 10 | |
| 315 | 6 | Oct 1, 2021 | 8:00 PM | Fri | (5) Iowa | 51 | @ | Maryland | 14 | |
| 316 | 6 | Oct 2, 2021 | 6:30 PM | Sat | Air Force | 38 | @ | New Mexico | 10 | |
| 317 | 6 | Oct 2, 2021 | 3:30 PM | Sat | (1) Alabama | 42 | | (12) Mississippi | 21 | |
| 318 | 6 | Oct 2, 2021 | 2:00 PM | Sat | Appalachian State | 45 | @ | Georgia State | 16 | |
| 319 | 6 | Oct 2, 2021 | 10:30 PM | Sat | Arizona State | 42 | @ | (20) UCLA | 23 | |
| 320 | 6 | Oct 2, 2021 | 9:00 PM | Sat | (22) Auburn | 24 | @ | Louisiana State | 19 | |
| 321 | 6 | Oct 2, 2021 | 5:00 PM | Sat | Ball State | 28 | | Army | 16 | |
| 322 | 6 | Oct 2, 2021 | 2:30 PM | Sat | (7) Cincinnati | 24 | @ | (9) Notre Dame | 13 | |
| 323 | 6 | Oct 2, 2021 | 7:30 PM | Sat | (25) Clemson | 19 | | Boston College | 13 | |
| 324 | 6 | Oct 2, 2021 | 2:30 PM | Sat | (16) Coastal Carolina | 59 | | Louisiana-Monroe | 6 | |
| 325 | 6 | Oct 2, 2021 | 3:30 PM | Sat | East Carolina | 52 | | Tulane | 29 | |
| 326 | 6 | Oct 2, 2021 | 3:30 PM | Sat | Florida Atlantic | 58 | | Florida International | 21 | |
| 327 | 6 | Oct 2, 2021 | 3:30 PM | Sat | Florida State | 33 | | Syracuse | 30 | |
| 328 | 6 | Oct 2, 2021 | 12:00 PM | Sat | (2) Georgia | 37 | | (8) Arkansas | 0 | |
| 329 | 6 | Oct 2, 2021 | 4:00 PM | Sat | Georgia Southern | 59 | | Arkansas State | 33 | |
| 330 | 6 | Oct 2, 2021 | 11:00 PM | Sat | Hawaii | 27 | | (18) Fresno State | 24 | |
| 331 | 6 | Oct 2, 2021 | 12:00 PM | Sat | Illinois | 24 | | Charlotte | 14 | |
| 332 | 6 | Oct 2, 2021 | 7:00 PM | Sat | Iowa State | 59 | | Kansas | 7 | |
| 333 | 6 | Oct 2, 2021 | 3:30 PM | Sat | Kent State | 27 | | Bowling Green | 20 | |
| 334 | 6 | Oct 2, 2021 | 6:00 PM | Sat | Kentucky | 20 | | (10) Florida | 13 | |
| 335 | 6 | Oct 2, 2021 | 7:00 PM | Sat | Liberty | 36 | @ | Alabama-Birmingham | 12 | |
| 336 | 6 | Oct 2, 2021 | 8:00 PM | Sat | Louisiana | 20 | @ | South Alabama | 18 | |
| 337 | 6 | Oct 2, 2021 | 3:30 PM | Sat | Miami (OH) | 28 | | Central Michigan | 17 | |
| 338 | 6 | Oct 2, 2021 | 12:00 PM | Sat | (14) Michigan | 38 | @ | Wisconsin | 17 | |
| 339 | 6 | Oct 2, 2021 | 7:30 PM | Sat | (17) Michigan State | 48 | | Western Kentucky | 31 | |
| 340 | 6 | Oct 2, 2021 | 7:00 PM | Sat | Middle Tennessee State | 34 | | Marshall | 28 | |
| 341 | 6 | Oct 2, 2021 | 12:00 PM | Sat | Minnesota | 20 | @ | Purdue | 13 | |
| 342 | 6 | Oct 2, 2021 | 7:00 PM | Sat | Mississippi State | 26 | @ | (15) Texas A&M | 22 | |
| 343 | 6 | Oct 2, 2021 | 3:30 PM | Sat | Navy | 34 | | Central Florida | 30 | |
| 344 | 6 | Oct 2, 2021 | 7:30 PM | Sat | Nebraska | 56 | | Northwestern | 7 | |
| 345 | 6 | Oct 2, 2021 | 3:30 PM | Sat | Nevada | 41 | @ | Boise State | 31 | |
| 346 | 6 | Oct 2, 2021 | 12:00 PM | Sat | North Carolina | 38 | | Duke | 7 | |
| 347 | 6 | Oct 2, 2021 | 6:00 PM | Sat | (23) North Carolina State | 34 | | Louisiana Tech | 27 | |
| 348 | 6 | Oct 2, 2021 | 2:30 PM | Sat | Northern Illinois | 27 | | Eastern Michigan | 20 | |
| 349 | 6 | Oct 2, 2021 | 3:30 PM | Sat | Ohio | 34 | @ | Akron | 17 | |
| 350 | 6 | Oct 2, 2021 | 3:30 PM | Sat | (11) Ohio State | 52 | @ | Rutgers | 13 | |
| 351 | 6 | Oct 2, 2021 | 3:30 PM | Sat | (6) Oklahoma | 37 | @ | Kansas State | 31 | |
| 352 | 6 | Oct 2, 2021 | 7:00 PM | Sat | (19) Oklahoma State | 24 | | (21) Baylor | 14 | |
| 353 | 6 | Oct 2, 2021 | 9:00 PM | Sat | Oregon State | 27 | | Washington | 24 | |
| 354 | 6 | Oct 2, 2021 | 7:30 PM | Sat | (4) Penn State | 24 | | Indiana | 0 | |
| 355 | 6 | Oct 2, 2021 | 12:00 PM | Sat | Pittsburgh | 52 | @ | Georgia Tech | 21 | |
| 356 | 6 | Oct 2, 2021 | 6:30 PM | Sat | Rice | 24 | | Southern Mississippi | 19 | |
| 357 | 6 | Oct 2, 2021 | 10:30 PM | Sat | San Jose State | 37 | | New Mexico State | 31 | |
| 358 | 6 | Oct 2, 2021 | 3:30 PM | Sat | South Carolina | 23 | | Troy | 14 | |
| 359 | 6 | Oct 2, 2021 | 2:00 PM | Sat | Southern California | 37 | @ | Colorado | 14 | |
| 360 | 6 | Oct 2, 2021 | 4:00 PM | Sat | Southern Methodist | 41 | | South Florida | 17 | |
| 361 | 6 | Oct 2, 2021 | 3:30 PM | Sat | Stanford | 31 | | (3) Oregon | 24 | |
| 362 | 6 | Oct 2, 2021 | 12:00 PM | Sat | Temple | 34 | | Memphis | 31 | |
| 363 | 6 | Oct 2, 2021 | 12:00 PM | Sat | Tennessee | 62 | @ | Missouri | 24 | |
| 364 | 6 | Oct 2, 2021 | 12:00 PM | Sat | Texas | 32 | @ | Texas Christian | 27 | |
| 365 | 6 | Oct 2, 2021 | 3:30 PM | Sat | Texas Tech | 23 | @ | West Virginia | 20 | |
| 366 | 6 | Oct 2, 2021 | 9:00 PM | Sat | Texas-El Paso | 28 | | Old Dominion | 21 | |
| 367 | 6 | Oct 2, 2021 | 6:00 PM | Sat | Texas-San Antonio | 24 | | Nevada-Las Vegas | 17 | |
| 368 | 6 | Oct 2, 2021 | 12:00 PM | Sat | Toledo | 45 | @ | Massachusetts | 7 | |
| 369 | 6 | Oct 2, 2021 | 7:30 PM | Sat | Vanderbilt | 30 | | Connecticut | 28 | |
| 370 | 6 | Oct 2, 2021 | 12:30 PM | Sat | (24) Wake Forest | 37 | | Louisville | 34 | |
| 371 | 6 | Oct 2, 2021 | 5:30 PM | Sat | Washington State | 21 | @ | California | 6 | |
| 372 | 6 | Oct 2, 2021 | 12:00 PM | Sat | Western Michigan | 24 | @ | Buffalo | 17 | |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 373 | 7 | Oct 7, 2021 | 7:30 PM | Thu | (15) Coastal Carolina | 52 | @ | Arkansas State | 20 | |
| 374 | 7 | Oct 7, 2021 | 7:30 PM | Thu | Houston | 40 | @ | Tulane | 22 | |
| 375 | 7 | Oct 8, 2021 | 10:30 PM | Fri | (22) Arizona State | 28 | | Stanford | 10 | |
| 376 | 7 | Oct 8, 2021 | 7:00 PM | Fri | Charlotte | 45 | @ | Florida International | 33 | |
| 377 | 7 | Oct 8, 2021 | 7:00 PM | Fri | (5) Cincinnati | 52 | | Temple | 3 | |
| 378 | 7 | Oct 9, 2021 | 7:00 PM | Sat | Air Force | 24 | | Wyoming | 14 | |
| 379 | 7 | Oct 9, 2021 | 12:00 PM | Sat | Akron | 35 | @ | Bowling Green | 20 | |
| 380 | 7 | Oct 9, 2021 | 3:30 PM | Sat | Alabama-Birmingham | 31 | | Florida Atlantic | 14 | |
| 381 | 7 | Oct 9, 2021 | 3:30 PM | Sat | Ball State | 45 | @ | Western Michigan | 20 | |
| 382 | 7 | Oct 9, 2021 | 12:00 PM | Sat | Baylor | 45 | | West Virginia | 20 | |
| 383 | 7 | Oct 9, 2021 | 3:30 PM | Sat | Boise State | 26 | @ | (10) Brigham Young | 17 | |
| 384 | 7 | Oct 9, 2021 | 6:00 PM | Sat | Central Florida | 20 | | East Carolina | 16 | |
| 385 | 7 | Oct 9, 2021 | 3:30 PM | Sat | Central Michigan | 30 | @ | Ohio | 27 | |
| 386 | 7 | Oct 9, 2021 | 3:30 PM | Sat | Colorado State | 32 | | San Jose State | 14 | |
| 387 | 7 | Oct 9, 2021 | 3:30 PM | Sat | Eastern Michigan | 13 | | Miami (OH) | 12 | |
| 388 | 7 | Oct 9, 2021 | 12:00 PM | Sat | (20) Florida | 42 | | Vanderbilt | 0 | |
| 389 | 7 | Oct 9, 2021 | 3:30 PM | Sat | Florida State | 35 | @ | North Carolina | 25 | |
| 390 | 7 | Oct 9, 2021 | 3:30 PM | Sat | (2) Georgia | 34 | @ | (18) Auburn | 10 | |
| 391 | 7 | Oct 9, 2021 | 8:00 PM | Sat | Georgia State | 55 | @ | Louisiana-Monroe | 21 | |
| 392 | 7 | Oct 9, 2021 | 12:30 PM | Sat | Georgia Tech | 31 | @ | Duke | 27 | |
| 393 | 7 | Oct 9, 2021 | 4:00 PM | Sat | (3) Iowa | 23 | | (4) Penn State | 20 | |
| 394 | 7 | Oct 9, 2021 | 7:00 PM | Sat | Kent State | 48 | | Buffalo | 38 | |
| 395 | 7 | Oct 9, 2021 | 7:30 PM | Sat | (16) Kentucky | 42 | | Louisiana State | 21 | |
| 396 | 7 | Oct 9, 2021 | 3:30 PM | Sat | Liberty | 41 | | Middle Tennessee State | 13 | |
| 397 | 7 | Oct 9, 2021 | 2:00 PM | Sat | Marshall | 20 | | Old Dominion | 13 | |
| 398 | 7 | Oct 9, 2021 | 3:30 PM | Sat | Massachusetts | 27 | | Connecticut | 13 | |
| 399 | 7 | Oct 9, 2021 | 7:30 PM | Sat | (9) Michigan | 32 | @ | Nebraska | 29 | |
| 400 | 7 | Oct 9, 2021 | 12:00 PM | Sat | (11) Michigan State | 31 | @ | Rutgers | 13 | |
| 401 | 7 | Oct 9, 2021 | 12:00 PM | Sat | (17) Mississippi | 52 | | (13) Arkansas | 51 | |
| 402 | 7 | Oct 9, 2021 | 4:00 PM | Sat | Missouri | 48 | | North Texas | 35 | |
| 403 | 7 | Oct 9, 2021 | 10:30 PM | Sat | Nevada | 55 | | New Mexico State | 28 | |
| 404 | 7 | Oct 9, 2021 | 12:00 PM | Sat | Northern Illinois | 22 | @ | Toledo | 20 | |
| 405 | 7 | Oct 9, 2021 | 7:30 PM | Sat | (14) Notre Dame | 32 | @ | Virginia Tech | 29 | |
| 406 | 7 | Oct 9, 2021 | 12:00 PM | Sat | (7) Ohio State | 66 | | Maryland | 17 | |
| 407 | 7 | Oct 9, 2021 | 12:00 PM | Sat | (6) Oklahoma | 55 | N | (21) Texas | 48 | Cotton Bowl - Dallas, Texas |
| 408 | 7 | Oct 9, 2021 | 9:00 PM | Sat | (25) San Diego State | 31 | | New Mexico | 7 | |
| 409 | 7 | Oct 9, 2021 | 3:30 PM | Sat | (24) Southern Methodist | 31 | @ | Navy | 24 | |
| 410 | 7 | Oct 9, 2021 | 12:00 PM | Sat | Tennessee | 45 | | South Carolina | 20 | |
| 411 | 7 | Oct 9, 2021 | 8:00 PM | Sat | Texas A&M | 41 | | (1) Alabama | 38 | |
| 412 | 7 | Oct 9, 2021 | 7:00 PM | Sat | Texas Christian | 52 | @ | Texas Tech | 31 | |
| 413 | 7 | Oct 9, 2021 | 7:00 PM | Sat | Texas State | 33 | | South Alabama | 31 | |
| 414 | 7 | Oct 9, 2021 | 7:00 PM | Sat | Texas-El Paso | 26 | @ | Southern Mississippi | 13 | |
| 415 | 7 | Oct 9, 2021 | 7:00 PM | Sat | Texas-San Antonio | 52 | @ | Western Kentucky | 46 | |
| 416 | 7 | Oct 9, 2021 | 7:00 PM | Sat | Troy | 27 | | Georgia Southern | 24 | |
| 417 | 7 | Oct 9, 2021 | 9:00 PM | Sat | Tulsa | 35 | | Memphis | 29 | |
| 418 | 7 | Oct 9, 2021 | 10:30 PM | Sat | UCLA | 34 | @ | Arizona | 16 | |
| 419 | 7 | Oct 9, 2021 | 8:00 PM | Sat | Utah | 42 | @ | Southern California | 26 | |
| 420 | 7 | Oct 9, 2021 | 3:00 PM | Sat | Virginia | 34 | @ | Louisville | 33 | |
| 421 | 7 | Oct 9, 2021 | 3:30 PM | Sat | (19) Wake Forest | 40 | @ | Syracuse | 37 | |
| 422 | 7 | Oct 9, 2021 | 4:00 PM | Sat | Washington State | 31 | | Oregon State | 24 | |
| 423 | 7 | Oct 9, 2021 | 3:30 PM | Sat | Wisconsin | 24 | @ | Illinois | 0 | |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 424 | 8 | Oct 12, 2021 | 7:30 PM | Tue | Louisiana | 41 | | Appalachian State | 13 | |
| 425 | 8 | Oct 14, 2021 | 7:30 PM | Thu | Memphis | 35 | | Navy | 17 | |
| 426 | 8 | Oct 14, 2021 | 7:30 PM | Thu | South Alabama | 41 | | Georgia Southern | 14 | |
| 427 | 8 | Oct 15, 2021 | 7:00 PM | Fri | Clemson | 17 | @ | Syracuse | 14 | |
| 428 | 8 | Oct 15, 2021 | 7:00 PM | Fri | Marshall | 49 | @ | North Texas | 21 | |
| 429 | 8 | Oct 15, 2021 | 10:30 PM | Fri | (9) Oregon | 24 | | California | 17 | |
| 430 | 8 | Oct 15, 2021 | 10:30 PM | Fri | (24) San Diego State | 19 | @ | San Jose State | 13 | |
| 431 | 8 | Oct 16, 2021 | 9:00 PM | Sat | Air Force | 24 | @ | Boise State | 17 | |
| 432 | 8 | Oct 16, 2021 | 7:00 PM | Sat | (5) Alabama | 49 | @ | Mississippi State | 9 | |
| 433 | 8 | Oct 16, 2021 | 3:30 PM | Sat | Alabama-Birmingham | 34 | @ | Southern Mississippi | 0 | |
| 434 | 8 | Oct 16, 2021 | 12:00 PM | Sat | Auburn | 38 | @ | (17) Arkansas | 23 | |
| 435 | 8 | Oct 16, 2021 | 2:00 PM | Sat | Ball State | 38 | @ | Eastern Michigan | 31 | |
| 436 | 8 | Oct 16, 2021 | 3:30 PM | Sat | Baylor | 38 | | (19) Brigham Young | 24 | |
| 437 | 8 | Oct 16, 2021 | 12:00 PM | Sat | Buffalo | 27 | | Ohio | 26 | |
| 438 | 8 | Oct 16, 2021 | 3:30 PM | Sat | Central Michigan | 26 | | Toledo | 23 | |
| 439 | 8 | Oct 16, 2021 | 12:00 PM | Sat | (3) Cincinnati | 56 | | Central Florida | 21 | |
| 440 | 8 | Oct 16, 2021 | 3:30 PM | Sat | Colorado | 34 | | Arizona | 0 | |
| 441 | 8 | Oct 16, 2021 | 7:00 PM | Sat | Colorado State | 36 | @ | New Mexico | 7 | |
| 442 | 8 | Oct 16, 2021 | 12:00 PM | Sat | Connecticut | 21 | | Yale | 15 | |
| 443 | 8 | Oct 16, 2021 | 3:30 PM | Sat | Fresno State | 17 | @ | Wyoming | 0 | |
| 444 | 8 | Oct 16, 2021 | 3:30 PM | Sat | (1) Georgia | 30 | | (11) Kentucky | 13 | |
| 445 | 8 | Oct 16, 2021 | 7:30 PM | Sat | Iowa State | 33 | @ | Kansas State | 20 | |
| 446 | 8 | Oct 16, 2021 | 12:00 PM | Sat | Louisiana State | 49 | | (20) Florida | 42 | |
| 447 | 8 | Oct 16, 2021 | 7:00 PM | Sat | Louisiana-Monroe | 31 | | Liberty | 28 | |
| 448 | 8 | Oct 16, 2021 | 2:30 PM | Sat | Miami (OH) | 34 | | Akron | 21 | |
| 449 | 8 | Oct 16, 2021 | 12:00 PM | Sat | (10) Michigan State | 20 | @ | Indiana | 15 | |
| 450 | 8 | Oct 16, 2021 | 12:00 PM | Sat | Minnesota | 30 | | Nebraska | 23 | |
| 451 | 8 | Oct 16, 2021 | 7:30 PM | Sat | (13) Mississippi | 31 | @ | Tennessee | 26 | |
| 452 | 8 | Oct 16, 2021 | 10:30 PM | Sat | Nevada | 34 | | Hawaii | 17 | |
| 453 | 8 | Oct 16, 2021 | 3:30 PM | Sat | North Carolina | 45 | | Miami (FL) | 42 | |
| 454 | 8 | Oct 16, 2021 | 7:30 PM | Sat | (22) North Carolina State | 33 | @ | Boston College | 7 | |
| 455 | 8 | Oct 16, 2021 | 3:30 PM | Sat | Northern Illinois | 34 | | Bowling Green | 26 | |
| 456 | 8 | Oct 16, 2021 | 12:00 PM | Sat | Northwestern | 21 | | Rutgers | 7 | |
| 457 | 8 | Oct 16, 2021 | 7:30 PM | Sat | (4) Oklahoma | 52 | | Texas Christian | 31 | |
| 458 | 8 | Oct 16, 2021 | 12:00 PM | Sat | (12) Oklahoma State | 32 | @ | (25) Texas | 24 | |
| 459 | 8 | Oct 16, 2021 | 3:30 PM | Sat | Pittsburgh | 28 | @ | Virginia Tech | 7 | |
| 460 | 8 | Oct 16, 2021 | 3:30 PM | Sat | Purdue | 24 | @ | (2) Iowa | 7 | |
| 461 | 8 | Oct 16, 2021 | 4:00 PM | Sat | South Carolina | 21 | | Vanderbilt | 20 | |
| 462 | 8 | Oct 16, 2021 | 12:00 PM | Sat | (21) Texas A&M | 35 | @ | Missouri | 14 | |
| 463 | 8 | Oct 16, 2021 | 4:00 PM | Sat | Texas Tech | 41 | @ | Kansas | 14 | |
| 464 | 8 | Oct 16, 2021 | 9:00 PM | Sat | Texas-El Paso | 19 | | Louisiana Tech | 3 | |
| 465 | 8 | Oct 16, 2021 | 6:00 PM | Sat | Texas-San Antonio | 45 | | Rice | 0 | |
| 466 | 8 | Oct 16, 2021 | 3:00 PM | Sat | Troy | 31 | @ | Texas State | 28 | |
| 467 | 8 | Oct 16, 2021 | 12:00 PM | Sat | Tulsa | 32 | @ | South Florida | 31 | |
| 468 | 8 | Oct 16, 2021 | 8:30 PM | Sat | UCLA | 24 | @ | Washington | 17 | |
| 469 | 8 | Oct 16, 2021 | 10:00 PM | Sat | Utah | 35 | | (18) Arizona State | 21 | |
| 470 | 8 | Oct 16, 2021 | 7:00 PM | Sat | Utah State | 28 | @ | Nevada-Las Vegas | 24 | |
| 471 | 8 | Oct 16, 2021 | 12:30 PM | Sat | Virginia | 48 | | Duke | 0 | |
| 472 | 8 | Oct 16, 2021 | 7:30 PM | Sat | Washington State | 34 | | Stanford | 31 | |
| 473 | 8 | Oct 16, 2021 | 3:30 PM | Sat | Western Kentucky | 43 | @ | Old Dominion | 20 | |
| 474 | 8 | Oct 16, 2021 | 3:30 PM | Sat | Western Michigan | 64 | | Kent State | 31 | |
| 475 | 8 | Oct 16, 2021 | 8:00 PM | Sat | Wisconsin | 20 | | Army | 14 | |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 476 | 9 | Oct 20, 2021 | 7:30 PM | Wed | Appalachian State | 30 | | (14) Coastal Carolina | 27 | |
| 477 | 9 | Oct 21, 2021 | 7:30 PM | Thu | Florida Atlantic | 38 | @ | Charlotte | 9 | |
| 478 | 9 | Oct 21, 2021 | 7:30 PM | Thu | Louisiana | 28 | @ | Arkansas State | 27 | |
| 479 | 9 | Oct 21, 2021 | 11:00 PM | Thu | San Jose State | 27 | @ | Nevada-Las Vegas | 20 | |
| 480 | 9 | Oct 21, 2021 | 7:30 PM | Thu | (21) Southern Methodist | 55 | | Tulane | 26 | |
| 481 | 9 | Oct 22, 2021 | 7:00 PM | Fri | Central Florida | 24 | | Memphis | 7 | |
| 482 | 9 | Oct 22, 2021 | 6:00 PM | Fri | Middle Tennessee State | 44 | @ | Connecticut | 13 | |
| 483 | 9 | Oct 22, 2021 | 9:30 PM | Fri | Utah State | 26 | | Colorado State | 24 | |
| 484 | 9 | Oct 22, 2021 | 10:30 PM | Fri | Washington | 21 | @ | Arizona | 16 | |
| 485 | 9 | Oct 23, 2021 | 7:00 PM | Sat | (4) Alabama | 52 | | Tennessee | 24 | |
| 486 | 9 | Oct 23, 2021 | 12:00 PM | Sat | Arkansas | 45 | | Arkansas-Pine Bluff | 3 | |
| 487 | 9 | Oct 23, 2021 | 3:30 PM | Sat | Brigham Young | 21 | @ | Washington State | 19 | |
| 488 | 9 | Oct 23, 2021 | 3:30 PM | Sat | Buffalo | 45 | @ | Akron | 10 | |
| 489 | 9 | Oct 23, 2021 | 3:30 PM | Sat | California | 26 | | Colorado | 3 | |
| 490 | 9 | Oct 23, 2021 | 12:00 PM | Sat | (2) Cincinnati | 27 | @ | Navy | 20 | |
| 491 | 9 | Oct 23, 2021 | 12:00 PM | Sat | Eastern Michigan | 55 | @ | Bowling Green | 24 | |
| 492 | 9 | Oct 23, 2021 | 12:00 PM | Sat | Florida State | 59 | | Massachusetts | 3 | |
| 493 | 9 | Oct 23, 2021 | 7:00 PM | Sat | Fresno State | 34 | | Nevada | 32 | |
| 494 | 9 | Oct 23, 2021 | 2:00 PM | Sat | Georgia State | 28 | | Texas State | 16 | |
| 495 | 9 | Oct 23, 2021 | 11:59 PM | Sat | Hawaii | 48 | | New Mexico State | 34 | |
| 496 | 9 | Oct 23, 2021 | 4:00 PM | Sat | Houston | 31 | | East Carolina | 24 | |
| 497 | 9 | Oct 23, 2021 | 12:00 PM | Sat | Illinois | 20 | @ | (7) Penn State | 18 | |
| 498 | 9 | Oct 23, 2021 | 3:30 PM | Sat | Iowa State | 24 | | (8) Oklahoma State | 21 | |
| 499 | 9 | Oct 23, 2021 | 12:00 PM | Sat | Kansas State | 25 | @ | Texas Tech | 24 | |
| 500 | 9 | Oct 23, 2021 | 1:00 PM | Sat | Kent State | 34 | @ | Ohio | 27 | |
| 501 | 9 | Oct 23, 2021 | 4:00 PM | Sat | Liberty | 35 | @ | North Texas | 26 | |
| 502 | 9 | Oct 23, 2021 | 7:00 PM | Sat | Louisiana-Monroe | 41 | | South Alabama | 31 | |
| 503 | 9 | Oct 23, 2021 | 4:00 PM | Sat | Louisville | 28 | | Boston College | 14 | |
| 504 | 9 | Oct 23, 2021 | 7:30 PM | Sat | Miami (FL) | 31 | | (18) North Carolina State | 30 | |
| 505 | 9 | Oct 23, 2021 | 3:30 PM | Sat | Miami (OH) | 24 | @ | Ball State | 17 | |
| 506 | 9 | Oct 23, 2021 | 12:00 PM | Sat | (6) Michigan | 33 | | Northwestern | 7 | |
| 507 | 9 | Oct 23, 2021 | 3:30 PM | Sat | Minnesota | 34 | | Maryland | 16 | |
| 508 | 9 | Oct 23, 2021 | 3:30 PM | Sat | (12) Mississippi | 31 | | Louisiana State | 17 | |
| 509 | 9 | Oct 23, 2021 | 4:00 PM | Sat | Mississippi State | 45 | @ | Vanderbilt | 6 | |
| 510 | 9 | Oct 23, 2021 | 3:30 PM | Sat | New Mexico | 14 | @ | Wyoming | 3 | |
| 511 | 9 | Oct 23, 2021 | 12:00 PM | Sat | Northern Illinois | 39 | @ | Central Michigan | 38 | |
| 512 | 9 | Oct 23, 2021 | 7:30 PM | Sat | (13) Notre Dame | 31 | | Southern California | 16 | |
| 513 | 9 | Oct 23, 2021 | 7:30 PM | Sat | (5) Ohio State | 54 | @ | Indiana | 7 | |
| 514 | 9 | Oct 23, 2021 | 12:00 PM | Sat | (3) Oklahoma | 35 | @ | Kansas | 23 | |
| 515 | 9 | Oct 23, 2021 | 3:30 PM | Sat | (10) Oregon | 34 | @ | UCLA | 31 | |
| 516 | 9 | Oct 23, 2021 | 7:30 PM | Sat | Oregon State | 42 | | Utah | 34 | |
| 517 | 9 | Oct 23, 2021 | 3:30 PM | Sat | (23) Pittsburgh | 27 | | Clemson | 17 | |
| 518 | 9 | Oct 23, 2021 | 3:30 PM | Sat | Rice | 30 | @ | Alabama-Birmingham | 24 | |
| 519 | 9 | Oct 23, 2021 | 7:00 PM | Sat | (22) San Diego State | 20 | @ | Air Force | 14 | |
| 520 | 9 | Oct 23, 2021 | 7:00 PM | Sat | South Florida | 34 | | Temple | 14 | |
| 521 | 9 | Oct 23, 2021 | 12:30 PM | Sat | Syracuse | 41 | @ | Virginia Tech | 36 | |
| 522 | 9 | Oct 23, 2021 | 7:30 PM | Sat | (17) Texas A&M | 44 | | South Carolina | 14 | |
| 523 | 9 | Oct 23, 2021 | 7:00 PM | Sat | (24) Texas-San Antonio | 45 | @ | Louisiana Tech | 16 | |
| 524 | 9 | Oct 23, 2021 | 3:30 PM | Sat | Toledo | 34 | | Western Michigan | 15 | |
| 525 | 9 | Oct 23, 2021 | 7:30 PM | Sat | Virginia | 48 | | Georgia Tech | 40 | |
| 526 | 9 | Oct 23, 2021 | 12:00 PM | Sat | (16) Wake Forest | 70 | @ | Army | 56 | |
| 527 | 9 | Oct 23, 2021 | 7:30 PM | Sat | West Virginia | 29 | @ | Texas Christian | 17 | |
| 528 | 9 | Oct 23, 2021 | 7:00 PM | Sat | Western Kentucky | 34 | @ | Florida International | 19 | |
| 529 | 9 | Oct 23, 2021 | 3:00 PM | Sat | Wisconsin | 30 | @ | (25) Purdue | 13 | |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 530 | 10 | Oct 28, 2021 | 7:30 PM | Thu | (24) Coastal Carolina | 35 | | Troy | 28 | |
| 531 | 10 | Oct 28, 2021 | 7:30 PM | Thu | East Carolina | 29 | | South Florida | 14 | |
| 532 | 10 | Oct 29, 2021 | 7:30 PM | Fri | Navy | 20 | @ | Tulsa | 17 | |
| 533 | 10 | Oct 29, 2021 | 10:00 PM | Fri | Nevada | 51 | | Nevada-Las Vegas | 20 | |
| 534 | 10 | Oct 30, 2021 | 3:30 PM | Sat | Appalachian State | 59 | | Louisiana-Monroe | 28 | |
| 535 | 10 | Oct 30, 2021 | 7:00 PM | Sat | (18) Auburn | 31 | | (10) Mississippi | 20 | |
| 536 | 10 | Oct 30, 2021 | 12:00 PM | Sat | (16) Baylor | 31 | | Texas | 24 | |
| 537 | 10 | Oct 30, 2021 | 7:00 PM | Sat | Boise State | 28 | @ | Colorado State | 19 | |
| 538 | 10 | Oct 30, 2021 | 12:00 PM | Sat | Bowling Green | 56 | @ | Buffalo | 44 | |
| 539 | 10 | Oct 30, 2021 | 10:15 PM | Sat | (25) Brigham Young | 66 | | Virginia | 49 | |
| 540 | 10 | Oct 30, 2021 | 7:00 PM | Sat | California | 39 | | Oregon State | 25 | |
| 541 | 10 | Oct 30, 2021 | 12:00 PM | Sat | Central Florida | 49 | @ | Temple | 7 | |
| 542 | 10 | Oct 30, 2021 | 12:00 PM | Sat | (2) Cincinnati | 31 | @ | Tulane | 12 | |
| 543 | 10 | Oct 30, 2021 | 3:30 PM | Sat | Clemson | 30 | | Florida State | 20 | |
| 544 | 10 | Oct 30, 2021 | 6:00 PM | Sat | Florida Atlantic | 28 | | Texas-El Paso | 25 | |
| 545 | 10 | Oct 30, 2021 | 10:30 PM | Sat | Fresno State | 30 | @ | (21) San Diego State | 20 | |
| 546 | 10 | Oct 30, 2021 | 3:30 PM | Sat | (1) Georgia | 34 | N | Florida | 7 | TIAA Bank Field - Jacksonville, Florida |
| 547 | 10 | Oct 30, 2021 | 6:00 PM | Sat | Georgia State | 21 | @ | Georgia Southern | 14 | |
| 548 | 10 | Oct 30, 2021 | 7:00 PM | Sat | Houston | 44 | | (19) Southern Methodist | 37 | |
| 549 | 10 | Oct 30, 2021 | 3:30 PM | Sat | Kansas State | 31 | | Texas Christian | 12 | |
| 550 | 10 | Oct 30, 2021 | 12:00 PM | Sat | Liberty | 62 | | Massachusetts | 17 | |
| 551 | 10 | Oct 30, 2021 | 12:00 PM | Sat | Louisiana | 45 | | Texas State | 0 | |
| 552 | 10 | Oct 30, 2021 | 3:30 PM | Sat | Marshall | 38 | | Florida International | 0 | |
| 553 | 10 | Oct 30, 2021 | 12:00 PM | Sat | Maryland | 38 | | Indiana | 35 | |
| 554 | 10 | Oct 30, 2021 | 12:00 PM | Sat | Miami (FL) | 38 | @ | (17) Pittsburgh | 34 | |
| 555 | 10 | Oct 30, 2021 | 12:00 PM | Sat | (8) Michigan State | 37 | | (6) Michigan | 33 | |
| 556 | 10 | Oct 30, 2021 | 3:30 PM | Sat | Middle Tennessee State | 35 | | Southern Mississippi | 10 | |
| 557 | 10 | Oct 30, 2021 | 3:30 PM | Sat | Minnesota | 41 | @ | Northwestern | 14 | |
| 558 | 10 | Oct 30, 2021 | 7:00 PM | Sat | Mississippi State | 31 | | (12) Kentucky | 17 | |
| 559 | 10 | Oct 30, 2021 | 3:00 PM | Sat | Missouri | 37 | @ | Vanderbilt | 28 | |
| 560 | 10 | Oct 30, 2021 | 7:30 PM | Sat | North Carolina State | 28 | | Louisville | 13 | |
| 561 | 10 | Oct 30, 2021 | 2:00 PM | Sat | North Texas | 30 | @ | Rice | 24 | |
| 562 | 10 | Oct 30, 2021 | 7:30 PM | Sat | (11) Notre Dame | 44 | | North Carolina | 34 | |
| 563 | 10 | Oct 30, 2021 | 7:30 PM | Sat | (5) Ohio State | 33 | | (20) Penn State | 24 | |
| 564 | 10 | Oct 30, 2021 | 3:30 PM | Sat | (4) Oklahoma | 52 | | Texas Tech | 21 | |
| 565 | 10 | Oct 30, 2021 | 7:00 PM | Sat | (15) Oklahoma State | 55 | | Kansas | 3 | |
| 566 | 10 | Oct 30, 2021 | 3:30 PM | Sat | Old Dominion | 23 | | Louisiana Tech | 20 | |
| 567 | 10 | Oct 30, 2021 | 3:30 PM | Sat | (7) Oregon | 52 | | Colorado | 29 | |
| 568 | 10 | Oct 30, 2021 | 3:30 PM | Sat | Purdue | 28 | @ | Nebraska | 23 | |
| 569 | 10 | Oct 30, 2021 | 12:00 PM | Sat | Rutgers | 20 | @ | Illinois | 14 | |
| 570 | 10 | Oct 30, 2021 | 4:00 PM | Sat | San Jose State | 27 | | Wyoming | 21 | |
| 571 | 10 | Oct 30, 2021 | 5:00 PM | Sat | South Alabama | 31 | | Arkansas State | 13 | |
| 572 | 10 | Oct 30, 2021 | 7:00 PM | Sat | Southern California | 41 | | Arizona | 34 | |
| 573 | 10 | Oct 30, 2021 | 3:30 PM | Sat | Syracuse | 21 | | Boston College | 6 | |
| 574 | 10 | Oct 30, 2021 | 10:00 PM | Sat | Utah | 44 | | UCLA | 24 | |
| 575 | 10 | Oct 30, 2021 | 3:00 PM | Sat | Utah State | 51 | | Hawaii | 31 | |
| 576 | 10 | Oct 30, 2021 | 12:00 PM | Sat | Virginia Tech | 26 | @ | Georgia Tech | 17 | |
| 577 | 10 | Oct 30, 2021 | 4:00 PM | Sat | (13) Wake Forest | 45 | | Duke | 7 | |
| 578 | 10 | Oct 30, 2021 | 10:30 PM | Sat | Washington | 20 | @ | Stanford | 13 | |
| 579 | 10 | Oct 30, 2021 | 3:00 PM | Sat | Washington State | 34 | @ | Arizona State | 21 | |
| 580 | 10 | Oct 30, 2021 | 2:00 PM | Sat | West Virginia | 38 | | (22) Iowa State | 31 | |
| 581 | 10 | Oct 30, 2021 | 4:00 PM | Sat | Western Kentucky | 45 | | Charlotte | 13 | |
| 582 | 10 | Oct 30, 2021 | 12:00 PM | Sat | Wisconsin | 27 | | (9) Iowa | 7 | |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 583 | 11 | Nov 2, 2021 | 7:00 PM | Tue | Ball State | 31 | @ | Akron | 25 | |
| 584 | 11 | Nov 2, 2021 | 7:30 PM | Tue | Eastern Michigan | 52 | @ | Toledo | 49 | |
| 585 | 11 | Nov 2, 2021 | 7:30 PM | Tue | Ohio | 35 | | Miami (OH) | 33 | |
| 586 | 11 | Nov 3, 2021 | 7:00 PM | Wed | Central Michigan | 42 | @ | Western Michigan | 30 | |
| 587 | 11 | Nov 3, 2021 | 7:00 PM | Wed | Kent State | 52 | | Northern Illinois | 47 | |
| 588 | 11 | Nov 4, 2021 | 7:30 PM | Thu | (24) Louisiana | 21 | | Georgia State | 17 | |
| 589 | 11 | Nov 5, 2021 | 7:30 PM | Fri | Boston College | 17 | | Virginia Tech | 3 | |
| 590 | 11 | Nov 5, 2021 | 10:30 PM | Fri | Utah | 52 | @ | Stanford | 7 | |
| 591 | 11 | Nov 6, 2021 | 7:00 PM | Sat | (3) Alabama | 20 | | Louisiana State | 14 | |
| 592 | 11 | Nov 6, 2021 | 12:00 PM | Sat | Alabama-Birmingham | 52 | | Louisiana Tech | 38 | |
| 593 | 11 | Nov 6, 2021 | 2:00 PM | Sat | Appalachian State | 48 | @ | Arkansas State | 14 | |
| 594 | 11 | Nov 6, 2021 | 3:00 PM | Sat | Arizona | 10 | | California | 3 | |
| 595 | 11 | Nov 6, 2021 | 10:30 PM | Sat | Arizona State | 31 | | Southern California | 16 | |
| 596 | 11 | Nov 6, 2021 | 4:00 PM | Sat | Arkansas | 31 | | Mississippi State | 28 | |
| 597 | 11 | Nov 6, 2021 | 11:30 AM | Sat | Army | 21 | N | Air Force | 14 | Globe Life Park - Arlington, Texas |
| 598 | 11 | Nov 6, 2021 | 7:00 PM | Sat | Boise State | 40 | @ | (25) Fresno State | 14 | |
| 599 | 11 | Nov 6, 2021 | 3:30 PM | Sat | (17) Brigham Young | 59 | | Idaho State | 14 | |
| 600 | 11 | Nov 6, 2021 | 4:00 PM | Sat | Central Florida | 14 | | Tulane | 10 | |
| 601 | 11 | Nov 6, 2021 | 3:30 PM | Sat | Charlotte | 31 | | Rice | 24 | |
| 602 | 11 | Nov 6, 2021 | 3:30 PM | Sat | (2) Cincinnati | 28 | | Tulsa | 20 | |
| 603 | 11 | Nov 6, 2021 | 7:30 PM | Sat | Clemson | 30 | @ | Louisville | 24 | |
| 604 | 11 | Nov 6, 2021 | 6:00 PM | Sat | (21) Coastal Carolina | 28 | @ | Georgia Southern | 8 | |
| 605 | 11 | Nov 6, 2021 | 7:00 PM | Sat | Colorado | 37 | | Oregon State | 34 | |
| 606 | 11 | Nov 6, 2021 | 3:00 PM | Sat | East Carolina | 45 | | Temple | 3 | |
| 607 | 11 | Nov 6, 2021 | 12:00 PM | Sat | (1) Georgia | 43 | | Missouri | 6 | |
| 608 | 11 | Nov 6, 2021 | 7:30 PM | Sat | (20) Houston | 54 | @ | South Florida | 42 | |
| 609 | 11 | Nov 6, 2021 | 12:00 PM | Sat | Illinois | 14 | @ | Minnesota | 6 | |
| 610 | 11 | Nov 6, 2021 | 7:00 PM | Sat | (19) Iowa | 17 | @ | Northwestern | 12 | |
| 611 | 11 | Nov 6, 2021 | 7:30 PM | Sat | Iowa State | 30 | | Texas | 7 | |
| 612 | 11 | Nov 6, 2021 | 12:00 PM | Sat | Kansas State | 35 | @ | Kansas | 10 | |
| 613 | 11 | Nov 6, 2021 | 6:00 PM | Sat | Marshall | 28 | @ | Florida Atlantic | 13 | |
| 614 | 11 | Nov 6, 2021 | 12:00 PM | Sat | Memphis | 28 | | (23) Southern Methodist | 25 | |
| 615 | 11 | Nov 6, 2021 | 12:30 PM | Sat | Miami (FL) | 33 | | Georgia Tech | 30 | |
| 616 | 11 | Nov 6, 2021 | 7:30 PM | Sat | (9) Michigan | 29 | | Indiana | 7 | |
| 617 | 11 | Nov 6, 2021 | 12:00 PM | Sat | (15) Mississippi | 27 | | Liberty | 14 | |
| 618 | 11 | Nov 6, 2021 | 10:00 PM | Sat | Nevada | 27 | | San Jose State | 24 | |
| 619 | 11 | Nov 6, 2021 | 7:00 PM | Sat | Nevada-Las Vegas | 31 | @ | New Mexico | 17 | |
| 620 | 11 | Nov 6, 2021 | 12:00 PM | Sat | North Carolina | 58 | | (10) Wake Forest | 55 | |
| 621 | 11 | Nov 6, 2021 | 4:00 PM | Sat | North Carolina State | 28 | @ | Florida State | 14 | |
| 622 | 11 | Nov 6, 2021 | 3:00 PM | Sat | North Texas | 38 | @ | Southern Mississippi | 14 | |
| 623 | 11 | Nov 6, 2021 | 3:30 PM | Sat | (8) Notre Dame | 34 | | Navy | 6 | |
| 624 | 11 | Nov 6, 2021 | 12:00 PM | Sat | (6) Ohio State | 26 | @ | Nebraska | 17 | |
| 625 | 11 | Nov 6, 2021 | 3:30 PM | Sat | (11) Oklahoma State | 24 | @ | West Virginia | 3 | |
| 626 | 11 | Nov 6, 2021 | 7:00 PM | Sat | Old Dominion | 47 | @ | Florida International | 24 | |
| 627 | 11 | Nov 6, 2021 | 7:30 PM | Sat | (7) Oregon | 26 | @ | Washington | 16 | |
| 628 | 11 | Nov 6, 2021 | 3:30 PM | Sat | (22) Penn State | 31 | @ | Maryland | 14 | |
| 629 | 11 | Nov 6, 2021 | 12:00 PM | Sat | Pittsburgh | 54 | @ | Duke | 29 | |
| 630 | 11 | Nov 6, 2021 | 3:30 PM | Sat | Purdue | 40 | | (5) Michigan State | 29 | |
| 631 | 11 | Nov 6, 2021 | 3:30 PM | Sat | Rhode Island | 35 | @ | Massachusetts | 22 | |
| 632 | 11 | Nov 6, 2021 | 11:00 PM | Sat | San Diego State | 17 | @ | Hawaii | 10 | |
| 633 | 11 | Nov 6, 2021 | 7:30 PM | Sat | South Carolina | 40 | | Florida | 17 | |
| 634 | 11 | Nov 6, 2021 | 7:00 PM | Sat | Tennessee | 45 | @ | (18) Kentucky | 42 | |
| 635 | 11 | Nov 6, 2021 | 3:30 PM | Sat | (13) Texas A&M | 20 | | (12) Auburn | 3 | |
| 636 | 11 | Nov 6, 2021 | 3:30 PM | Sat | Texas Christian | 30 | | (14) Baylor | 28 | |
| 637 | 11 | Nov 6, 2021 | 3:00 PM | Sat | Texas State | 27 | | Louisiana-Monroe | 19 | |
| 638 | 11 | Nov 6, 2021 | 10:15 PM | Sat | (16) Texas-San Antonio | 44 | @ | Texas-El Paso | 23 | |
| 639 | 11 | Nov 6, 2021 | 3:30 PM | Sat | Troy | 31 | | South Alabama | 24 | |
| 640 | 11 | Nov 6, 2021 | 4:00 PM | Sat | Utah State | 35 | @ | New Mexico State | 13 | |
| 641 | 11 | Nov 6, 2021 | 3:30 PM | Sat | Western Kentucky | 48 | | Middle Tennessee State | 21 | |
| 642 | 11 | Nov 6, 2021 | 3:30 PM | Sat | Wisconsin | 52 | @ | Rutgers | 3 | |
| 643 | 11 | Nov 6, 2021 | 3:30 PM | Sat | Wyoming | 31 | | Colorado State | 17 | |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 644 | 12 | Nov 9, 2021 | 7:00 PM | Tue | Miami (OH) | 45 | | Buffalo | 18 | |
| 645 | 12 | Nov 9, 2021 | 8:00 PM | Tue | Ohio | 34 | @ | Eastern Michigan | 26 | |
| 646 | 12 | Nov 9, 2021 | 7:00 PM | Tue | Western Michigan | 45 | | Akron | 40 | |
| 647 | 12 | Nov 10, 2021 | 8:00 PM | Wed | Central Michigan | 54 | | Kent State | 30 | |
| 648 | 12 | Nov 10, 2021 | 7:00 PM | Wed | Northern Illinois | 30 | | Ball State | 29 | |
| 649 | 12 | Nov 10, 2021 | 7:00 PM | Wed | Toledo | 49 | @ | Bowling Green | 17 | |
| 650 | 12 | Nov 11, 2021 | 7:30 PM | Thu | (25) Pittsburgh | 30 | | North Carolina | 23 | |
| 651 | 12 | Nov 12, 2021 | 9:00 PM | Fri | Boise State | 23 | | Wyoming | 13 | |
| 652 | 12 | Nov 12, 2021 | 6:00 PM | Fri | (2) Cincinnati | 45 | @ | South Florida | 28 | |
| 653 | 12 | Nov 13, 2021 | 7:00 PM | Sat | Air Force | 35 | @ | Colorado State | 21 | |
| 654 | 12 | Nov 13, 2021 | 12:00 PM | Sat | (3) Alabama | 59 | | New Mexico State | 3 | |
| 655 | 12 | Nov 13, 2021 | 3:30 PM | Sat | Alabama-Birmingham | 21 | @ | Marshall | 14 | |
| 656 | 12 | Nov 13, 2021 | 2:30 PM | Sat | Appalachian State | 31 | | South Alabama | 7 | |
| 657 | 12 | Nov 13, 2021 | 7:00 PM | Sat | Arizona State | 35 | @ | Washington | 30 | |
| 658 | 12 | Nov 13, 2021 | 7:30 PM | Sat | Arkansas | 16 | @ | Louisiana State | 13 | |
| 659 | 12 | Nov 13, 2021 | 5:00 PM | Sat | Arkansas State | 27 | @ | Louisiana-Monroe | 24 | |
| 660 | 12 | Nov 13, 2021 | 12:00 PM | Sat | Army | 63 | | Bucknell | 10 | |
| 661 | 12 | Nov 13, 2021 | 12:00 PM | Sat | (18) Baylor | 27 | | (4) Oklahoma | 14 | |
| 662 | 12 | Nov 13, 2021 | 3:30 PM | Sat | Boston College | 41 | @ | Georgia Tech | 30 | |
| 663 | 12 | Nov 13, 2021 | 12:00 PM | Sat | Clemson | 44 | | Connecticut | 7 | |
| 664 | 12 | Nov 13, 2021 | 12:00 PM | Sat | East Carolina | 30 | @ | Memphis | 29 | |
| 665 | 12 | Nov 13, 2021 | 12:00 PM | Sat | Florida | 70 | | Samford | 52 | |
| 666 | 12 | Nov 13, 2021 | 3:30 PM | Sat | Florida State | 31 | | Miami (FL) | 28 | |
| 667 | 12 | Nov 13, 2021 | 7:00 PM | Sat | Fresno State | 34 | | New Mexico | 7 | |
| 668 | 12 | Nov 13, 2021 | 3:30 PM | Sat | (1) Georgia | 41 | @ | Tennessee | 17 | |
| 669 | 12 | Nov 13, 2021 | 3:00 PM | Sat | Georgia Southern | 38 | @ | Texas State | 30 | |
| 670 | 12 | Nov 13, 2021 | 2:00 PM | Sat | Georgia State | 42 | @ | (22) Coastal Carolina | 40 | |
| 671 | 12 | Nov 13, 2021 | 12:00 PM | Sat | (17) Houston | 37 | @ | Temple | 8 | |
| 672 | 12 | Nov 13, 2021 | 3:30 PM | Sat | (19) Iowa | 27 | | Minnesota | 22 | |
| 673 | 12 | Nov 13, 2021 | 7:30 PM | Sat | Kansas | 57 | @ | Texas | 56 | |
| 674 | 12 | Nov 13, 2021 | 12:00 PM | Sat | Kansas State | 34 | | West Virginia | 17 | |
| 675 | 12 | Nov 13, 2021 | 7:00 PM | Sat | Kentucky | 34 | @ | Vanderbilt | 17 | |
| 676 | 12 | Nov 13, 2021 | 3:30 PM | Sat | (24) Louisiana | 35 | @ | Troy | 21 | |
| 677 | 12 | Nov 13, 2021 | 3:30 PM | Sat | Louisiana Tech | 42 | | Charlotte | 32 | |
| 678 | 12 | Nov 13, 2021 | 12:00 PM | Sat | Louisville | 41 | | Syracuse | 3 | |
| 679 | 12 | Nov 13, 2021 | 12:00 PM | Sat | Maine | 35 | @ | Massachusetts | 10 | |
| 680 | 12 | Nov 13, 2021 | 12:00 PM | Sat | (9) Michigan | 21 | @ | (23) Penn State | 17 | |
| 681 | 12 | Nov 13, 2021 | 4:00 PM | Sat | (8) Michigan State | 40 | | Maryland | 21 | |
| 682 | 12 | Nov 13, 2021 | 3:30 PM | Sat | Middle Tennessee State | 50 | | Florida International | 10 | |
| 683 | 12 | Nov 13, 2021 | 7:00 PM | Sat | (12) Mississippi | 29 | | (11) Texas A&M | 19 | |
| 684 | 12 | Nov 13, 2021 | 12:00 PM | Sat | Mississippi State | 43 | @ | (16) Auburn | 34 | |
| 685 | 12 | Nov 13, 2021 | 4:00 PM | Sat | Missouri | 31 | | South Carolina | 28 | |
| 686 | 12 | Nov 13, 2021 | 4:00 PM | Sat | Nevada-Las Vegas | 27 | | Hawaii | 13 | |
| 687 | 12 | Nov 13, 2021 | 4:00 PM | Sat | North Texas | 20 | | Texas-El Paso | 17 | |
| 688 | 12 | Nov 13, 2021 | 7:30 PM | Sat | (7) Notre Dame | 28 | @ | Virginia | 3 | |
| 689 | 12 | Nov 13, 2021 | 3:30 PM | Sat | (6) Ohio State | 59 | | Purdue | 31 | |
| 690 | 12 | Nov 13, 2021 | 8:00 PM | Sat | (10) Oklahoma State | 63 | | Texas Christian | 17 | |
| 691 | 12 | Nov 13, 2021 | 3:30 PM | Sat | Old Dominion | 30 | | Florida Atlantic | 16 | |
| 692 | 12 | Nov 13, 2021 | 10:30 PM | Sat | (5) Oregon | 38 | | Washington State | 24 | |
| 693 | 12 | Nov 13, 2021 | 5:30 PM | Sat | Oregon State | 35 | | Stanford | 14 | |
| 694 | 12 | Nov 13, 2021 | 12:00 PM | Sat | Rutgers | 38 | @ | Indiana | 3 | |
| 695 | 12 | Nov 13, 2021 | 10:30 PM | Sat | San Diego State | 23 | | Nevada | 21 | |
| 696 | 12 | Nov 13, 2021 | 12:00 PM | Sat | Southern Methodist | 55 | | Central Florida | 28 | |
| 697 | 12 | Nov 13, 2021 | 3:30 PM | Sat | Texas Tech | 41 | | Iowa State | 38 | |
| 698 | 12 | Nov 13, 2021 | 3:30 PM | Sat | (15) Texas-San Antonio | 27 | | Southern Mississippi | 17 | |
| 699 | 12 | Nov 13, 2021 | 4:00 PM | Sat | Tulsa | 20 | @ | Tulane | 13 | |
| 700 | 12 | Nov 13, 2021 | 9:00 PM | Sat | UCLA | 44 | | Colorado | 20 | |
| 701 | 12 | Nov 13, 2021 | 2:00 PM | Sat | Utah | 38 | @ | Arizona | 29 | |
| 702 | 12 | Nov 13, 2021 | 10:30 PM | Sat | Utah State | 48 | @ | San Jose State | 17 | |
| 703 | 12 | Nov 13, 2021 | 3:30 PM | Sat | Virginia Tech | 48 | | Duke | 17 | |
| 704 | 12 | Nov 13, 2021 | 7:30 PM | Sat | (13) Wake Forest | 45 | | (21) North Carolina State | 42 | |
| 705 | 12 | Nov 13, 2021 | 2:00 PM | Sat | Western Kentucky | 42 | @ | Rice | 21 | |
| 706 | 12 | Nov 13, 2021 | 12:00 PM | Sat | (20) Wisconsin | 35 | | Northwestern | 7 | |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 707 | 13 | Nov 16, 2021 | 7:30 PM | Tue | Eastern Michigan | 22 | | Western Michigan | 21 | |
| 708 | 13 | Nov 16, 2021 | 8:00 PM | Tue | Miami (OH) | 34 | | Bowling Green | 7 | |
| 709 | 13 | Nov 16, 2021 | 7:00 PM | Tue | Toledo | 35 | @ | Ohio | 23 | |
| 710 | 13 | Nov 17, 2021 | 7:00 PM | Wed | Central Michigan | 37 | @ | Ball State | 17 | |
| 711 | 13 | Nov 17, 2021 | 7:00 PM | Wed | Northern Illinois | 33 | @ | Buffalo | 27 | |
| 712 | 13 | Nov 18, 2021 | 7:30 PM | Thu | Louisville | 62 | @ | Duke | 22 | |
| 713 | 13 | Nov 19, 2021 | 9:00 PM | Fri | Air Force | 41 | @ | Nevada | 39 | |
| 714 | 13 | Nov 19, 2021 | 9:00 PM | Fri | (17) Houston | 31 | | Memphis | 13 | |
| 715 | 13 | Nov 19, 2021 | 11:30 PM | Fri | (23) San Diego State | 28 | @ | Nevada-Las Vegas | 20 | |
| 716 | 13 | Nov 19, 2021 | 8:00 PM | Fri | Southern Mississippi | 35 | @ | Louisiana Tech | 19 | |
| 717 | 13 | Nov 19, 2021 | 9:00 PM | Fri | Washington State | 44 | | Arizona | 18 | |
| 718 | 13 | Nov 20, 2021 | 3:30 PM | Sat | (2) Alabama | 42 | | (21) Arkansas | 35 | |
| 719 | 13 | Nov 20, 2021 | 3:30 PM | Sat | Appalachian State | 45 | @ | Troy | 7 | |
| 720 | 13 | Nov 20, 2021 | 12:00 PM | Sat | Army | 33 | | Massachusetts | 17 | |
| 721 | 13 | Nov 20, 2021 | 5:30 PM | Sat | (11) Baylor | 20 | @ | Kansas State | 10 | |
| 722 | 13 | Nov 20, 2021 | 9:00 PM | Sat | Boise State | 37 | | New Mexico | 0 | |
| 723 | 13 | Nov 20, 2021 | 4:00 PM | Sat | (14) Brigham Young | 34 | @ | Georgia Southern | 17 | |
| 724 | 13 | Nov 20, 2021 | 7:00 PM | Sat | California | 41 | @ | Stanford | 11 | |
| 725 | 13 | Nov 20, 2021 | 4:00 PM | Sat | Central Florida | 49 | | Connecticut | 17 | |
| 726 | 13 | Nov 20, 2021 | 3:30 PM | Sat | (3) Cincinnati | 48 | | Southern Methodist | 14 | |
| 727 | 13 | Nov 20, 2021 | 12:00 PM | Sat | Clemson | 48 | | (13) Wake Forest | 27 | |
| 728 | 13 | Nov 20, 2021 | 1:00 PM | Sat | Coastal Carolina | 35 | | Texas State | 21 | |
| 729 | 13 | Nov 20, 2021 | 3:00 PM | Sat | Colorado | 20 | | Washington | 17 | |
| 730 | 13 | Nov 20, 2021 | 3:30 PM | Sat | East Carolina | 38 | @ | Navy | 35 | |
| 731 | 13 | Nov 20, 2021 | 12:00 PM | Sat | Florida State | 26 | @ | Boston College | 23 | |
| 732 | 13 | Nov 20, 2021 | 12:00 PM | Sat | (1) Georgia | 56 | | Charleston Southern | 7 | |
| 733 | 13 | Nov 20, 2021 | 2:00 PM | Sat | Georgia State | 28 | | Arkansas State | 20 | |
| 734 | 13 | Nov 20, 2021 | 11:00 PM | Sat | Hawaii | 50 | | Colorado State | 45 | |
| 735 | 13 | Nov 20, 2021 | 2:00 PM | Sat | (18) Iowa | 33 | | Illinois | 23 | |
| 736 | 13 | Nov 20, 2021 | 12:00 PM | Sat | Kent State | 38 | @ | Akron | 0 | |
| 737 | 13 | Nov 20, 2021 | 12:00 PM | Sat | Kentucky | 56 | | New Mexico State | 16 | |
| 738 | 13 | Nov 20, 2021 | 4:00 PM | Sat | (22) Louisiana | 42 | @ | Liberty | 14 | |
| 739 | 13 | Nov 20, 2021 | 9:00 PM | Sat | Louisiana State | 27 | | Louisiana-Monroe | 14 | |
| 740 | 13 | Nov 20, 2021 | 3:30 PM | Sat | Marshall | 49 | @ | Charlotte | 28 | |
| 741 | 13 | Nov 20, 2021 | 7:30 PM | Sat | Miami (FL) | 38 | | Virginia Tech | 26 | |
| 742 | 13 | Nov 20, 2021 | 3:30 PM | Sat | (8) Michigan | 59 | @ | Maryland | 18 | |
| 743 | 13 | Nov 20, 2021 | 3:30 PM | Sat | Minnesota | 35 | @ | Indiana | 14 | |
| 744 | 13 | Nov 20, 2021 | 7:30 PM | Sat | (10) Mississippi | 31 | | Vanderbilt | 17 | |
| 745 | 13 | Nov 20, 2021 | 12:00 PM | Sat | Mississippi State | 55 | | Tennessee State | 10 | |
| 746 | 13 | Nov 20, 2021 | 4:00 PM | Sat | Missouri | 24 | | Florida | 23 | |
| 747 | 13 | Nov 20, 2021 | 12:00 PM | Sat | North Carolina | 34 | | Wofford | 14 | |
| 748 | 13 | Nov 20, 2021 | 4:00 PM | Sat | (25) North Carolina State | 41 | | Syracuse | 17 | |
| 749 | 13 | Nov 20, 2021 | 7:00 PM | Sat | North Texas | 49 | @ | Florida International | 7 | |
| 750 | 13 | Nov 20, 2021 | 2:30 PM | Sat | (6) Notre Dame | 55 | | Georgia Tech | 0 | |
| 751 | 13 | Nov 20, 2021 | 12:00 PM | Sat | (5) Ohio State | 56 | | (7) Michigan State | 7 | |
| 752 | 13 | Nov 20, 2021 | 12:00 PM | Sat | (12) Oklahoma | 28 | | Iowa State | 21 | |
| 753 | 13 | Nov 20, 2021 | 8:00 PM | Sat | (9) Oklahoma State | 23 | @ | Texas Tech | 0 | |
| 754 | 13 | Nov 20, 2021 | 3:30 PM | Sat | Old Dominion | 24 | @ | Middle Tennessee State | 17 | |
| 755 | 13 | Nov 20, 2021 | 10:30 PM | Sat | Oregon State | 24 | | Arizona State | 10 | |
| 756 | 13 | Nov 20, 2021 | 12:00 PM | Sat | Penn State | 28 | | Rutgers | 0 | |
| 757 | 13 | Nov 20, 2021 | 3:30 PM | Sat | (20) Pittsburgh | 48 | | Virginia | 38 | |
| 758 | 13 | Nov 20, 2021 | 12:00 PM | Sat | Purdue | 32 | N | Northwestern | 14 | Wrigley Field - Chicago, Illinois |
| 759 | 13 | Nov 20, 2021 | 7:00 PM | Sat | South Carolina | 21 | | Auburn | 17 | |
| 760 | 13 | Nov 20, 2021 | 7:30 PM | Sat | Tennessee | 60 | | South Alabama | 14 | |
| 761 | 13 | Nov 20, 2021 | 12:00 PM | Sat | (16) Texas A&M | 52 | | Prairie View A&M | 3 | |
| 762 | 13 | Nov 20, 2021 | 4:00 PM | Sat | Texas Christian | 31 | | Kansas | 28 | |
| 763 | 13 | Nov 20, 2021 | 4:00 PM | Sat | Texas-El Paso | 38 | | Rice | 28 | |
| 764 | 13 | Nov 20, 2021 | 3:30 PM | Sat | (15) Texas-San Antonio | 34 | | Alabama-Birmingham | 31 | |
| 765 | 13 | Nov 20, 2021 | 12:00 PM | Sat | Tulane | 45 | | South Florida | 14 | |
| 766 | 13 | Nov 20, 2021 | 4:00 PM | Sat | Tulsa | 44 | | Temple | 10 | |
| 767 | 13 | Nov 20, 2021 | 4:00 PM | Sat | UCLA | 62 | @ | Southern California | 33 | |
| 768 | 13 | Nov 20, 2021 | 7:30 PM | Sat | (24) Utah | 38 | | (4) Oregon | 7 | |
| 769 | 13 | Nov 20, 2021 | 12:00 PM | Sat | West Virginia | 31 | | Texas | 23 | |
| 770 | 13 | Nov 20, 2021 | 12:00 PM | Sat | Western Kentucky | 52 | | Florida Atlantic | 17 | |
| 771 | 13 | Nov 20, 2021 | 3:30 PM | Sat | (19) Wisconsin | 35 | | Nebraska | 28 | |
| 772 | 13 | Nov 20, 2021 | 8:00 PM | Sat | Wyoming | 44 | @ | Utah State | 17 | |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 773 | 14 | Nov 23, 2021 | 7:00 PM | Tue | Ball State | 20 | | Buffalo | 3 | |
| 774 | 14 | Nov 23, 2021 | 7:00 PM | Tue | Western Michigan | 42 | @ | Northern Illinois | 21 | |
| 775 | 14 | Nov 25, 2021 | 3:30 PM | Thu | Fresno State | 40 | @ | San Jose State | 9 | |
| 776 | 14 | Nov 25, 2021 | 7:30 PM | Thu | (8) Mississippi | 31 | @ | Mississippi State | 21 | |
| 777 | 14 | Nov 26, 2021 | 3:30 PM | Fri | Air Force | 48 | | Nevada-Las Vegas | 14 | |
| 778 | 14 | Nov 26, 2021 | 2:00 PM | Fri | Alabama-Birmingham | 42 | | Texas-El Paso | 25 | |
| 779 | 14 | Nov 26, 2021 | 3:30 PM | Fri | (25) Arkansas | 34 | | Missouri | 17 | |
| 780 | 14 | Nov 26, 2021 | 12:00 PM | Fri | Bowling Green | 21 | | Ohio | 10 | |
| 781 | 14 | Nov 26, 2021 | 3:30 PM | Fri | Central Florida | 17 | | South Florida | 13 | |
| 782 | 14 | Nov 26, 2021 | 12:00 PM | Fri | Central Michigan | 31 | | Eastern Michigan | 10 | |
| 783 | 14 | Nov 26, 2021 | 3:50 PM | Fri | (4) Cincinnati | 35 | @ | East Carolina | 13 | |
| 784 | 14 | Nov 26, 2021 | 3:30 PM | Fri | Coastal Carolina | 27 | @ | South Alabama | 21 | |
| 785 | 14 | Nov 26, 2021 | 1:30 PM | Fri | (17) Iowa | 28 | @ | Nebraska | 21 | |
| 786 | 14 | Nov 26, 2021 | 4:30 PM | Fri | Iowa State | 48 | | Texas Christian | 14 | |
| 787 | 14 | Nov 26, 2021 | 7:00 PM | Fri | (24) North Carolina State | 34 | | North Carolina | 30 | |
| 788 | 14 | Nov 26, 2021 | 12:00 PM | Fri | (22) San Diego State | 27 | | Boise State | 16 | |
| 789 | 14 | Nov 26, 2021 | 12:00 PM | Fri | Texas | 22 | | Kansas State | 17 | |
| 790 | 14 | Nov 26, 2021 | 4:00 PM | Fri | (16) Utah | 28 | | Colorado | 13 | |
| 791 | 14 | Nov 26, 2021 | 1:00 PM | Fri | Utah State | 35 | @ | New Mexico | 10 | |
| 792 | 14 | Nov 26, 2021 | 8:00 PM | Fri | Washington State | 40 | @ | Washington | 13 | |
| 793 | 14 | Nov 27, 2021 | 3:30 PM | Sat | (3) Alabama | 24 | @ | Auburn | 22 | |
| 794 | 14 | Nov 27, 2021 | 2:30 PM | Sat | Appalachian State | 27 | | Georgia Southern | 3 | |
| 795 | 14 | Nov 27, 2021 | 4:00 PM | Sat | Arizona State | 38 | | Arizona | 15 | |
| 796 | 14 | Nov 27, 2021 | 12:00 PM | Sat | Army | 31 | @ | Liberty | 16 | |
| 797 | 14 | Nov 27, 2021 | 12:00 PM | Sat | (9) Baylor | 27 | | Texas Tech | 24 | |
| 798 | 14 | Nov 27, 2021 | 10:30 PM | Sat | (13) Brigham Young | 35 | @ | Southern California | 31 | |
| 799 | 14 | Nov 27, 2021 | 7:30 PM | Sat | Clemson | 30 | @ | South Carolina | 0 | |
| 800 | 14 | Nov 27, 2021 | 12:00 PM | Sat | Florida | 24 | | Florida State | 21 | |
| 801 | 14 | Nov 27, 2021 | 12:00 PM | Sat | (1) Georgia | 45 | @ | Georgia Tech | 0 | |
| 802 | 14 | Nov 27, 2021 | 2:00 PM | Sat | Georgia State | 37 | | Troy | 10 | |
| 803 | 14 | Nov 27, 2021 | 3:00 PM | Sat | Hawaii | 38 | @ | Wyoming | 14 | |
| 804 | 14 | Nov 27, 2021 | 12:00 PM | Sat | (19) Houston | 45 | @ | Connecticut | 17 | |
| 805 | 14 | Nov 27, 2021 | 3:30 PM | Sat | Illinois | 47 | | Northwestern | 14 | |
| 806 | 14 | Nov 27, 2021 | 12:00 PM | Sat | Kent State | 48 | | Miami (OH) | 47 | |
| 807 | 14 | Nov 27, 2021 | 7:30 PM | Sat | Kentucky | 52 | @ | Louisville | 21 | |
| 808 | 14 | Nov 27, 2021 | 4:00 PM | Sat | (23) Louisiana | 21 | | Louisiana-Monroe | 16 | |
| 809 | 14 | Nov 27, 2021 | 7:00 PM | Sat | Louisiana State | 27 | | (14) Texas A&M | 24 | |
| 810 | 14 | Nov 27, 2021 | 12:00 PM | Sat | Maryland | 40 | @ | Rutgers | 16 | |
| 811 | 14 | Nov 27, 2021 | 7:30 PM | Sat | Memphis | 33 | | Tulane | 28 | |
| 812 | 14 | Nov 27, 2021 | 12:30 PM | Sat | Miami (FL) | 47 | @ | Duke | 10 | |
| 813 | 14 | Nov 27, 2021 | 12:00 PM | Sat | (6) Michigan | 42 | | (2) Ohio State | 27 | |
| 814 | 14 | Nov 27, 2021 | 3:30 PM | Sat | (12) Michigan State | 30 | | Penn State | 27 | |
| 815 | 14 | Nov 27, 2021 | 7:00 PM | Sat | Middle Tennessee State | 27 | @ | Florida Atlantic | 17 | |
| 816 | 14 | Nov 27, 2021 | 4:00 PM | Sat | Minnesota | 23 | | (18) Wisconsin | 13 | |
| 817 | 14 | Nov 27, 2021 | 12:00 PM | Sat | Navy | 38 | @ | Temple | 14 | |
| 818 | 14 | Nov 27, 2021 | 9:00 PM | Sat | Nevada | 52 | @ | Colorado State | 10 | |
| 819 | 14 | Nov 27, 2021 | 3:00 PM | Sat | New Mexico State | 44 | | Massachusetts | 27 | |
| 820 | 14 | Nov 27, 2021 | 2:00 PM | Sat | North Texas | 45 | | (15) Texas-San Antonio | 23 | |
| 821 | 14 | Nov 27, 2021 | 8:00 PM | Sat | (5) Notre Dame | 45 | @ | Stanford | 14 | |
| 822 | 14 | Nov 27, 2021 | 7:30 PM | Sat | (7) Oklahoma State | 37 | | (10) Oklahoma | 33 | |
| 823 | 14 | Nov 27, 2021 | 2:00 PM | Sat | Old Dominion | 56 | | Charlotte | 34 | |
| 824 | 14 | Nov 27, 2021 | 3:30 PM | Sat | (11) Oregon | 38 | | Oregon State | 29 | |
| 825 | 14 | Nov 27, 2021 | 7:30 PM | Sat | (20) Pittsburgh | 31 | @ | Syracuse | 14 | |
| 826 | 14 | Nov 27, 2021 | 3:30 PM | Sat | Purdue | 44 | | Indiana | 7 | |
| 827 | 14 | Nov 27, 2021 | 1:00 PM | Sat | Rice | 35 | | Louisiana Tech | 31 | |
| 828 | 14 | Nov 27, 2021 | 3:00 PM | Sat | Southern Mississippi | 37 | | Florida International | 17 | |
| 829 | 14 | Nov 27, 2021 | 3:45 PM | Sat | Tennessee | 45 | | Vanderbilt | 21 | |
| 830 | 14 | Nov 27, 2021 | 2:00 PM | Sat | Texas State | 24 | @ | Arkansas State | 22 | |
| 831 | 14 | Nov 27, 2021 | 12:00 PM | Sat | Toledo | 49 | | Akron | 14 | |
| 832 | 14 | Nov 27, 2021 | 4:00 PM | Sat | Tulsa | 34 | @ | Southern Methodist | 31 | |
| 833 | 14 | Nov 27, 2021 | 10:30 PM | Sat | UCLA | 42 | | California | 14 | |
| 834 | 14 | Nov 27, 2021 | 3:45 PM | Sat | Virginia Tech | 29 | @ | Virginia | 24 | |
| 835 | 14 | Nov 27, 2021 | 12:00 PM | Sat | (21) Wake Forest | 41 | @ | Boston College | 10 | |
| 836 | 14 | Nov 27, 2021 | 7:00 PM | Sat | West Virginia | 34 | @ | Kansas | 28 | |
| 837 | 14 | Nov 27, 2021 | 3:30 PM | Sat | Western Kentucky | 53 | @ | Marshall | 21 | |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 838 | 15 | Dec 3, 2021 | 7:00 PM | Fri | Texas-San Antonio | 49 | | Western Kentucky | 41 | Conference USA Championship (San Antonio, TX) |
| 839 | 15 | Dec 3, 2021 | 8:00 PM | Fri | (14) Utah | 38 | N | (10) Oregon | 10 | Pac-12 Championship (Paradise, NV) |
| 840 | 15 | Dec 4, 2021 | 4:00 PM | Sat | (4) Alabama | 41 | N | (1) Georgia | 24 | SEC Championship (Atlanta, GA) |
| 841 | 15 | Dec 4, 2021 | 12:00 PM | Sat | (9) Baylor | 21 | N | (5) Oklahoma State | 16 | Big 12 Championship (Arlington, TX) |
| 842 | 15 | Dec 4, 2021 | 11:00 PM | Sat | California | 24 | | Southern California | 14 | |
| 843 | 15 | Dec 4, 2021 | 4:00 PM | Sat | (3) Cincinnati | 35 | | (16) Houston | 20 | American Athletic Conference Championship (Cincinnati, OH) |
| 844 | 15 | Dec 4, 2021 | 3:30 PM | Sat | (20) Louisiana | 24 | | Appalachian State | 16 | Sun Belt Championship (Lafayette, LA) |
| 845 | 15 | Dec 4, 2021 | 8:00 PM | Sat | (2) Michigan | 42 | N | (15) Iowa | 3 | Big Ten Championship (Indianapolis, IN) |
| 846 | 15 | Dec 4, 2021 | 12:00 PM | Sat | Northern Illinois | 41 | N | Kent State | 23 | MAC Championship (Detroit, MI) |
| 847 | 15 | Dec 4, 2021 | 8:00 PM | Sat | (17) Pittsburgh | 45 | N | (18) Wake Forest | 21 | ACC Championship (Charlotte, NC) |
| 848 | 15 | Dec 4, 2021 | 3:00 PM | Sat | Utah State | 46 | @ | (19) San Diego State | 13 | MWC Championship (Carson, CA) |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 849 | 16 | Dec 11, 2021 | 3:00 PM | Sat | Navy | 17 | N | Army | 13 | MetLife Stadium - East Rutherford, New Jersey |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 850 | 17 | Dec 17, 2021 | 6:00 PM | Fri | Coastal Carolina | 47 | N | Northern Illinois | 41 | Cure Bowl (Exploria Stadium - Orlando, Florida) |
| 851 | 17 | Dec 17, 2021 | 12:00 PM | Fri | Middle Tennessee State | 31 | N | Toledo | 24 | Bahamas Bowl (Thomas A. Robinson Stadium - Nassau, BHS) |
| 852 | 17 | Dec 18, 2021 | 3:30 PM | Sat | Alabama-Birmingham | 31 | N | (12) Brigham Young | 28 | Independence Bowl (Independence Stadium - Shreveport, Louisiana) |
| 853 | 17 | Dec 18, 2021 | 2:15 PM | Sat | Fresno State | 31 | N | Texas-El Paso | 24 | New Mexico Bowl (University Stadium (Albuquerque) - Albuquerque, New Mexico) |
| 854 | 17 | Dec 18, 2021 | 5:45 PM | Sat | Liberty | 56 | N | Eastern Michigan | 20 | LendingTree Bowl (Hancock Whitney Stadium - Mobile, Alabama) |
| 855 | 17 | Dec 18, 2021 | 9:15 PM | Sat | (16) Louisiana | 36 | N | Marshall | 21 | New Orleans Bowl (Caesars Superdome - New Orleans, Louisiana) |
| 856 | 17 | Dec 18, 2021 | 7:30 PM | Sat | Utah State | 24 | N | Oregon State | 13 | LA Bowl (SoFi Stadium - Inglewood, California) |
| 857 | 17 | Dec 18, 2021 | 11:00 AM | Sat | Western Kentucky | 59 | N | Appalachian State | 38 | Boca Raton Bowl (FAU Stadium - Boca Raton, Florida) |
| 858 | 17 | Dec 20, 2021 | 2:30 PM | Mon | Tulsa | 30 | N | Old Dominion | 17 | Myrtle Beach Bowl (Brooks Stadium - Conway, South Carolina) |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 859 | 18 | Dec 21, 2021 | 7:30 PM | Tue | San Diego State | 38 | N | (24) Texas-San Antonio | 24 | Frisco Bowl (Toyota Stadium - Frisco, Texas) |
| 860 | 18 | Dec 21, 2021 | 3:30 PM | Tue | Wyoming | 52 | N | Kent State | 38 | Famous Idaho Potato Bowl (Albertsons Stadium - Boise, Idaho) |
| 861 | 18 | Dec 22, 2021 | 8:00 PM | Wed | Army | 24 | N | Missouri | 22 | Armed Forces Bowl (Amon G. Carter Stadium - Fort Worth, Texas) |
| 862 | 18 | Dec 23, 2021 | | Thu | Army | 24 | N | Missouri | 22 | |
| 863 | 18 | Dec 23, 2021 | 7:00 PM | Thu | Central Florida | 29 | N | Florida | 17 | Union Home Mortgage Gasparilla Bowl (Raymond James Stadium - Tampa, Florida) |
| 864 | 18 | Dec 23, 2021 | 3:30 PM | Thu | Miami (OH) | 27 | N | North Texas | 14 | Frisco Football Classic (Toyota Stadium - Frisco, Texas) |
| 865 | 18 | Dec 25, 2021 | 2:30 PM | Sat | Georgia State | 51 | N | Ball State | 20 | Camellia Bowl (Cramton Bowl - Montgomery, Alabama) |
| 866 | 18 | Dec 27, 2021 | 11:00 AM | Mon | Western Michigan | 52 | N | Nevada | 24 | Quick Lane Bowl (Ford Field - Detroit, Michigan) |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 867 | 19 | Dec 28, 2021 | 3:15 PM | Tue | Air Force | 31 | N | Louisville | 28 | First Responder Bowl (Gerald J. Ford Stadium - Dallas, Texas) |
| 868 | 19 | Dec 28, 2021 | 12:00 PM | Tue | (21) Houston | 17 | N | Auburn | 13 | Birmingham Bowl (Protective Stadium - Birmingham, Alabama) |
| 869 | 19 | Dec 28, 2021 | 10:15 PM | Tue | Minnesota | 18 | N | West Virginia | 6 | Guaranteed Rate Bowl (Chase Field - Phoenix, Arizona) |
| 870 | 19 | Dec 28, 2021 | 6:45 PM | Tue | Texas Tech | 34 | N | Mississippi State | 7 | Liberty Bowl (Liberty Bowl Memorial Stadium - Memphis, Tennessee) |
| 871 | 19 | Dec 29, 2021 | 5:45 PM | Wed | (19) Clemson | 20 | N | Iowa State | 13 | Cheez-It Bowl (Camping World Stadium - Orlando, Florida) |
| 872 | 19 | Dec 29, 2021 | 2:15 PM | Wed | Maryland | 54 | N | Virginia Tech | 10 | Pinstripe Bowl (Yankee Stadium - New York, New York) |
| 873 | 19 | Dec 29, 2021 | 9:15 PM | Wed | (14) Oklahoma | 47 | N | (15) Oregon | 32 | Alamo Bowl (Alamodome - San Antonio, Texas) |
| 874 | 19 | Dec 30, 2021 | 7:00 PM | Thu | (11) Michigan State | 31 | N | (13) Pittsburgh | 21 | Peach Bowl (Mercedes-Benz Stadium - Atlanta, Georgia) |
| 875 | 19 | Dec 30, 2021 | 3:00 PM | Thu | Purdue | 48 | N | Tennessee | 45 | Music City Bowl (Nissan Stadium - Nashville, Tennessee) |
| 876 | 19 | Dec 30, 2021 | 11:30 AM | Thu | South Carolina | 38 | N | North Carolina | 21 | Duke's Mayo Bowl (Bank of America Stadium - Charlotte, North Carolina) |
| 877 | 19 | Dec 30, 2021 | 10:30 PM | Thu | Wisconsin | 20 | N | Arizona State | 13 | Las Vegas Bowl (Allegiant Stadium - Paradise, Nevada) |
| 878 | 19 | Dec 31, 2021 | 3:30 PM | Fri | (1) Alabama | 27 | N | (4) Cincinnati | 6 | Cotton Bowl (AT&T Stadium - Arlington, Texas) |
| 879 | 19 | Dec 31, 2021 | 12:00 PM | Fri | Central Michigan | 24 | N | Washington State | 21 | Sun Bowl (Sun Bowl - El Paso, Texas) |
| 880 | 19 | Dec 31, 2021 | 7:30 PM | Fri | (3) Georgia | 34 | N | (2) Michigan | 11 | Orange Bowl (Hard Rock Stadium - Miami Gardens, Florida) |
| 881 | 19 | Dec 31, 2021 | 11:00 AM | Fri | (20) Wake Forest | 38 | N | Rutgers | 10 | Gator Bowl (TIAA Bank Field - Jacksonville, Florida) |
| 882 | 19 | Jan 1, 2022 | 12:00 PM | Sat | (22) Arkansas | 24 | N | Penn State | 10 | Outback Bowl (Raymond James Stadium - Tampa, Florida) |
| 883 | 19 | Jan 1, 2022 | 8:45 PM | Sat | (6) Baylor | 21 | N | (8) Mississippi | 7 | Sugar Bowl (Caesars Superdome - New Orleans, Louisiana) |
| 884 | 19 | Jan 1, 2022 | 1:00 PM | Sat | (25) Kentucky | 20 | N | (17) Iowa | 17 | Citrus Bowl (Camping World Stadium - Orlando, Florida) |
| 885 | 19 | Jan 1, 2022 | 5:00 PM | Sat | (7) Ohio State | 48 | N | (10) Utah | 45 | Rose Bowl (Rose Bowl - Pasadena, California) |
| 886 | 19 | Jan 1, 2022 | 1:00 PM | Sat | (9) Oklahoma State | 37 | N | (5) Notre Dame | 35 | Fiesta Bowl (State Farm Stadium - Glendale, Arizona) |
| Rk |
Wk |
Date |
Time |
Day |
Winner |
Pts |
|
Loser |
Pts |
Notes |
| 887 | 20 | Jan 4, 2022 | 9:00 PM | Tue | Kansas State | 42 | N | Louisiana State | 20 | Texas Bowl (NRG Stadium - Houston, Texas) |
| 888 | 20 | Jan 10, 2022 | 8:00 PM | Mon | (3) Georgia | 33 | N | (1) Alabama | 18 | College Football Playoff National Championship (Lucas Oil Stadium - Indianapolis, Indiana) |
We're Social...for Statheads
Site Last Updated: Tuesday, June 9, 7:36AM
Question, Comment, Feedback, or Correction?
Subscribe to our Free Email Newsletter
Do you have a sports website? Or write about sports? We have tools and resources that can help you use sports data. Find out more.