| 1 | Sep 4, 2016 | 7:30 PM | Sun | Texas | | (10) Notre Dame | Ind | W | 50 | 47 | 1 | 0 | W 1 | Darrell K Royal-Texas Memorial Stadium - Austin, Texas |
| 2 | Sep 10, 2016 | 7:00 PM | Sat | (11) Texas | | UTEP | CUSA | W | 41 | 7 | 2 | 0 | W 2 | Darrell K Royal-Texas Memorial Stadium - Austin, Texas |
| 3 | Sep 17, 2016 | 10:30 PM | Sat | (11) Texas | @ | California | Pac-12 | L | 43 | 50 | 2 | 1 | L 1 | Memorial Stadium - Berkeley, California |
| 4 | Oct 1, 2016 | 12:00 PM | Sat | (22) Texas | @ | Oklahoma State | Big 12 | L | 31 | 49 | 2 | 2 | L 2 | Boone Pickens Stadium - Stillwater, Oklahoma |
| 5 | Oct 8, 2016 | 12:00 PM | Sat | Texas | N | (20) Oklahoma | Big 12 | L | 40 | 45 | 2 | 3 | L 3 | Cotton Bowl Stadium - Dallas, Texas |
| 6 | Oct 15, 2016 | 7:00 PM | Sat | Texas | | Iowa State | Big 12 | W | 27 | 6 | 3 | 3 | W 1 | Darrell K Royal-Texas Memorial Stadium - Austin, Texas |
| 7 | Oct 22, 2016 | 12:00 PM | Sat | Texas | @ | Kansas State | Big 12 | L | 21 | 24 | 3 | 4 | L 1 | Bill Snyder Family Football Stadium - Manhattan, Kansas |
| 8 | Oct 29, 2016 | 3:30 PM | Sat | Texas | | (8) Baylor | Big 12 | W | 35 | 34 | 4 | 4 | W 1 | Darrell K Royal-Texas Memorial Stadium - Austin, Texas |
| 9 | Nov 5, 2016 | 12:00 PM | Sat | Texas | @ | Texas Tech | Big 12 | W | 45 | 37 | 5 | 4 | W 2 | Jones AT&T Stadium - Lubbock, Texas |
| 10 | Nov 12, 2016 | 12:00 PM | Sat | Texas | | (11) West Virginia | Big 12 | L | 20 | 24 | 5 | 5 | L 1 | Darrell K Royal-Texas Memorial Stadium - Austin, Texas |
| 11 | Nov 19, 2016 | 3:30 PM | Sat | Texas | @ | Kansas | Big 12 | L | 21 | 24 | 5 | 6 | L 2 | Memorial Stadium - Lawrence, Kansas |
| 12 | Nov 25, 2016 | 3:30 PM | Fri | Texas | | Texas Christian | Big 12 | L | 9 | 31 | 5 | 7 | L 3 | Darrell K Royal-Texas Memorial Stadium - Austin, Texas |
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