| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 16 | 1 | 2022-09-03 | Ohio State | Notre Dame | REG (Non-Conf) | W 21-10 | |
| 2 | 17 | 2 | 2022-09-10 | Ohio State | Arkansas State | REG (Non-Conf) | W 45-12 | |
| 3 | 18 | 3 | 2022-09-17 | Ohio State | Toledo | REG (Non-Conf) | W 77-21 | |
| 4 | 19 | 4 | 2022-09-24 | Ohio State | Wisconsin | REG (Conf) | W 52-21 | |
| 5 | 20 | 5 | 2022-10-01 | Ohio State | Rutgers | REG (Conf) | W 49-10 | |
| 6 | 21 | 6 | 2022-10-08 | Ohio State | @ | Michigan State | REG (Conf) | W 49-20 |
| 7 | 22 | 7 | 2022-10-22 | Ohio State | Iowa | REG (Conf) | W 54-10 | |
| 8 | 23 | 8 | 2022-10-29 | Ohio State | @ | Penn State | REG (Conf) | W 44-31 |
| 9 | 24 | 9 | 2022-11-05 | Ohio State | @ | Northwestern | REG (Conf) | W 21-7 |
| 10 | 25 | 10 | 2022-11-12 | Ohio State | Indiana | REG (Conf) | W 56-14 | |
| 11 | 26 | 11 | 2022-11-19 | Ohio State | @ | Maryland | REG (Conf) | W 43-30 |
| 12 | 27 | 12 | 2022-11-26 | Ohio State | Michigan | REG (Conf) | L 23-45 | |
| 11-1 |
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