12 Games
- Conference games only
| Rk | Date | Day | Winner | Pts | Loser | Pts | Notes | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oct 8, 1921 | Sat | Baylor | 17 | Rice | 14 | ||
| Rk | Date | Day | Winner | Pts | Loser | Pts | Notes | |
| 2 | Oct 12, 1921 | Wed | Texas A&M | 13 | @ | Southern Methodist | 0 | |
| Rk | Date | Day | Winner | Pts | Loser | Pts | Notes | |
| 3 | Oct 22, 1921 | Sat | Oklahoma State | 7 | Arkansas | 0 | ||
| Rk | Date | Day | Winner | Pts | Loser | Pts | Notes | |
| 4 | Oct 29, 1921 | Sat | Arkansas | 14 | Southern Methodist | 0 | ||
| 5 | Oct 29, 1921 | Sat | Texas | 56 | Rice | 0 | ||
| 6 | Oct 29, 1921 | Sat | Texas A&M | 23 | Oklahoma State | 7 | ||
| Rk | Date | Day | Winner | Pts | Loser | Pts | Notes | |
| 7 | Nov 5, 1921 | Sat | Rice | 7 | Southern Methodist | 0 | ||
| 8 | Nov 5, 1921 | Sat | Texas A&M | 14 | @ | Baylor | 3 | |
| Rk | Date | Day | Winner | Pts | Loser | Pts | Notes | |
| 9 | Nov 11, 1921 | Fri | Texas A&M | 7 | @ | Rice | 7 | |
| Rk | Date | Day | Winner | Pts | Loser | Pts | Notes | |
| 10 | Nov 19, 1921 | Sat | Arkansas | 13 | Baylor | 12 | ||
| Rk | Date | Day | Winner | Pts | Loser | Pts | Notes | |
| 11 | Nov 24, 1921 | Thu | Texas | 0 | @ | Texas A&M | 0 | |
| 12 | Nov 26, 1921 | Sat | Baylor | 28 | Southern Methodist | 0 |
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